Evidence map›Paper›PMID 35215642›Full record

ArticlePolymers2022

Polymeric Coating of Silica Microspheres for Biological Applications: Suppression of Non-Specific Binding and Functionalization with Biomolecules.

Dario Brambilla, Alessandro Mussida, Anna M Ferretti, Laura Sola, Francesco Damin, Marcella Chiari

Abstract read
In one paragraph

Article in Polymers, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Extracellular vesicles isolation: a focus on magnetic beads-assisted platforms.Frontiers in bioengineering and biotechnology · 2025
    Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dario BrambillaInstitute of Chemical Science and Technology "G. Natta", National Research Council of Italy (CNR-SCITEC), 20131 Milan, Italy.ORCID 0000-0003-3490-4481
Alessandro MussidaInstitute of Chemical Science and Technology "G. Natta", National Research Council of Italy (CNR-SCITEC), 20131 Milan, Italy.
Anna M FerrettiInstitute of Chemical Science and Technology "G. Natta", National Research Council of Italy (CNR-SCITEC), 20131 Milan, Italy.ORCID 0000-0002-7373-7965
Laura SolaInstitute of Chemical Science and Technology "G. Natta", National Research Council of Italy (CNR-SCITEC), 20131 Milan, Italy.ORCID 0000-0002-2603-0318
Francesco DaminInstitute of Chemical Science and Technology "G. Natta", National Research Council of Italy (CNR-SCITEC), 20131 Milan, Italy.ORCID 0000-0003-1780-7823
Marcella ChiariInstitute of Chemical Science and Technology "G. Natta", National Research Council of Italy (CNR-SCITEC), 20131 Milan, Italy.

Funding

European Union 766466
6 · The paper itself

Abstract

The use of micro- and nanoparticles in biological applications has dramatically grown during the last few decades due to the ease of protocols development and compatibility with microfluidics devices. Particles can be composed by different materials, i.e., polymers, inorganic dielectrics, and metals. Among them, silica is a suitable material for the development of biosensing applications. Depending on their final application, the surface properties of particles, including silica, are tailored by means of chemical modification or polymeric coating. The latter strategy represents a powerful tool to create a hydrophilic environment that enables the functionalization of particles with biomolecules and the further interaction with analytes. Here, the use of MCP-6, a dimethylacrylamide (DMA)-based ter-copolymer, to coat silica microspheres is presented. MCP-6 offers unprecedented ease of coating, imparting silica particles a hydrophilic coating with antifouling properties that is able to provide high-density immobilization of biological probes.

Indexed as

biomoleculesbiosensingcoatingDNAmicroparticlespolymerproteinsilicastreptavidin

Identifiers

PMID35215642
PMCPMC8877092

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.