Evidence map›Paper›PMID 35215528›Full record

ArticleNutrients2022

Vitamin D Is Associated with Clinical Outcomes in Patients with Primary Biliary Cholangitis.

Maryam Ebadi, Stephen Ip, Ellina Lytvyak, Somayyeh Asghari, Elora Rider, Andrew Mason, Aldo J Montano-Loza

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 23 citations in OpenAlex.

  1. Trial
  2. Review
  3. Pathogenesis, Non-Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  4. Article
  5. Bile acids and their receptors in hepatic immunity.Liver research (Beijing, China) · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Maryam EbadiDivision of Gastroenterology & Liver Unit, Department of Medicine, University of Alberta Hospital, Edmonton, AB T6G 2X8, Canada.
Stephen IpDivision of Gastroenterology & Liver Unit, Department of Medicine, University of Alberta Hospital, Edmonton, AB T6G 2X8, Canada.
Ellina LytvyakDivision of Gastroenterology & Liver Unit, Department of Medicine, University of Alberta Hospital, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0001-5651-9010
Somayyeh AsghariDepartment of Clinical Nutrition, Faculty of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran 14176-13151, Iran.
Elora RiderDivision of Gastroenterology & Liver Unit, Department of Medicine, University of Alberta Hospital, Edmonton, AB T6G 2X8, Canada.
Andrew MasonDivision of Gastroenterology & Liver Unit, Department of Medicine, University of Alberta Hospital, Edmonton, AB T6G 2X8, Canada.
Aldo J Montano-LozaDivision of Gastroenterology & Liver Unit, Department of Medicine, University of Alberta Hospital, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0002-2511-7980
Alberta Hospital Edmonton · CATehran University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vitamin D (VD) deficiency has been associated with clinical outcomes in patients with chronic liver disease. This study aims to identify the prevalence of VD deficiency in patients with primary biliary cholangitis (PBC) and its association with treatment response to ursodeoxycholic acid (UDCA), cirrhosis development, and liver-related events (mortality and liver transplantation). Two hundred and fifty-five patients with PBC diagnosis were evaluated. Patients with VD levels below 50 nmol/L were defined as deficient. Treatment response to UDCA was defined according to the Toronto criteria. Independent risk factors were identified using binary logistic and Cox regression analysis. The mean level of serum VD was 77 ± 39 nmol/L, and 64 patients (25%) were VD deficient. Incomplete response to UDCA was more prevalent in VD-deficient patients compared to their counterparts (45% vs. 22%;

Indexed as

Liver Cirrhosis, BiliaryLiver TransplantationCholagogues and CholereticsHumansTreatment OutcomeUrsodeoxycholic AcidVitamin DCholagogues and CholereticsUrsodeoxycholic AcidVitamin Dchronic cholestasiscirrhosis developmentliver-related mortalitylow vitamin D levelstreatment failure

Identifiers

PMID35215528
PMCPMC8878051
OpenAlexW4214694720

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.