Evidence map›Paper›PMID 35215473›Full record

ArticleNutrients2022

Dietary Linolenic Acid Increases Sensitizing and Eliciting Capacities of Cow's Milk Whey Proteins in BALB/c Mice.

Xuanyi Meng, Yong Wu, Xuefang Wen, Jinyan Gao, Yanhai Xie, Xiaoli Zhao, Jin Yuan, Hao Yang, Zheling Zeng, Xin Li and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Xuanyi MengState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0002-0314-2077
Yong WuState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0001-9840-940X
Xuefang WenInstiute of Applied Chemistry, Jiangxi Academy of Sciences, Nanchang 330096, China.
Jinyan GaoState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0003-2180-297X
Yanhai XieState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Xiaoli ZhaoState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Jin YuanState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Hao YangState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Zheling ZengState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Xin LiState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
Hongbing ChenState Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.ORCID 0000-0002-4845-383X
Nanchang University · CNJiangxi Academy of Sciences · CN

Funding

National Natural Science Foundation of China 31872887
6 · The paper itself

Abstract

α-Lactalbumin (BLA) and β-lactoglobulin (BLG) are the major whey proteins causing allergic reactions. Polyunsaturated fatty acids (PUFAs) stand among the extrinsic factors of the food matrix that can bind BLA and BLG and change their bioactivities, but their contribution to change the allergenic properties of these proteins has not been investigated. Here, we aimed to determine how PUFAs influence BLA and BLG to sensitize and trigger allergic responses in BALB/c mice. First, tricine-SDS-PAGE and spectroscopic assays identified that α-linolenic acid (ALA, as a proof-of-concept model) can induce BLA and BLG to form cross-linked complexes and substantially modify their conformation. Then, BALB/c mice (

Indexed as

Milk Hypersensitivityalpha-Linolenic AcidAnimalsCattleFemaleMiceMice, Inbred BALB CMilkMilk ProteinsWhey Proteinsalpha-Linolenic AcidMilk ProteinsWhey Proteinsallergic reactioncomponents interactionlinolenic acidpolyunsaturated fatty acidswhey proteins

Identifiers

PMID35215473
PMCPMC8877816
OpenAlexW4212869547

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.