ArticleNutrients2022
Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study.
Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Associations between dietary fibers and gut microbiome composition in the EDIA longitudinal infant cohort.The American journal of clinical nutrition · 2025Article
- Diversity of complementary diet and early food allergy risk.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Article
- Scientific developments in understanding food allergy prevention, diagnosis, and treatment.Frontiers in immunology · 2025Review
- Skin and oral intervention for food allergy prevention based on dual allergen exposure hypothesis.Clinical and experimental pediatrics · 2024Article
- Feasibility and Safety of the Early Introduction of Allergenic Foods in Asian Infants with Eczema.Nutrients · 2024Article
- Consumption of cow's milk formula in the nursery and the development of milk allergy.Clinical and translational allergy · 2024Article
- Early Introduction of Novel and Less-Studied Food Allergens in the Plant-Based Era: Considerations for US and EU Infant Formula Regulations.Nutrients · 2023Review
- Immunonutrition: Diet Diversity, Gut Microbiome and Prevention of Allergic Diseases.Allergy, asthma & immunology research · 2023Review
- The Relevance of Nutrition for Pediatric Allergy and Immunity.Nutrients · 2023Article
- Food allergy prevention: Where are we in 2023?Asia Pacific allergy · 2023Review
- Allergy: Mechanistic insights into new methods of prevention and therapy.Science translational medicine · 2023Review
- Advances and potential of omics studies for understanding the development of food allergy.Frontiers in allergy · 2023Review
- Correction: Quake et al. Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy: Pilot Study. Nutrients 2022, 14, 737Nutrients · 2022Article
- Relevance of Early Introduction of Cow's Milk Proteins for Prevention of Cow's Milk Allergy.Nutrients · 2022Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The incidence and prevalence of food allergy (FA) is increasing. While several studies have established the safety and efficacy of early introduction of single allergens in infants for the prevention of FA, the exact dose, frequency, and number of allergens that can be safely introduced to infants, particularly in those at high or low risk of atopy, are still unclear. This 1-year pilot study evaluated the safety of the early introduction of single foods (milk, egg, or peanut) vs. two foods (milk/egg, egg/peanut, milk/peanut) vs. multiple foods (milk/egg/peanut/cashew/almond/shrimp/walnut/wheat/salmon/hazelnut at low, medium, or high doses) vs. no early introduction in 180 infants between 4-6 months of age. At the end of the study, they were evaluated for plasma biomarkers associated with food reactivity via standardized blood tests. Two to four years after the start of the study, participants were evaluated by standardized food challenges. The serving sizes for the single, double, and low dose mixtures were 300 mg total protein per day. The serving sizes for the medium and high dose mixtures were 900 mg and 3000 mg total protein, respectively. Equal parts of each protein were used for double or mixture foods. All infants were breastfed until at least six months of age. The results demonstrate that infants at either high or low risk for atopy were able to tolerate the early introduction of multiple allergenic foods with no increases in any safety issues, including eczema, FA, or food protein induced enterocolitis. The mixtures of foods at either low, medium, or high doses demonstrated trends for improvement in food challenge reactivity and plasma biomarkers compared to single and double food introductions. The results of this study suggest that the early introduction of foods, particularly simultaneous mixtures of many allergenic foods, may be safe and efficacious for preventing FA and can occur safely. These results need to be confirmed by larger randomized controlled studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.