Evidence map›Paper›PMID 35215385›Full record

ArticleNutrients2022

Integrative Metabolomic Characterization Reveals the Mediating Effect of

Guangsu Zhu, Min Guo, Jianxin Zhao, Hao Zhang, Gang Wang, Wei Chen

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.

  1. Nutrients · 2025
    Pooled it
  2. Nutrients · 2023
    Trial
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Metabolic Regulations ofMetabolites · 2024
    Article
  11. Microbiota regulation by differentFood science and biotechnology · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Guangsu ZhuState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-9501-7379
Min GuoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jianxin ZhaoState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Hao ZhangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0002-9192-4684
Gang WangState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.ORCID 0000-0003-2007-2143
Wei ChenState Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
Jiangnan University · CN

Funding

Fundamental Research Funds for the Central Universities JUSRP22006Fundamental Research Funds for the Central Universities JUSRP51501National Natural Science Foundation of China 31820103010National Natural Science Foundation of China 31972052National Natural Science Foundation of China 32021005Program of Collaborative Innovation Centre of Food Safety and Quality Control in Jiangsu Province None
6 · The paper itself

Abstract

Alzheimer's disease (AD) is commonly accompanied by global alterations in metabolic profiles, resulting in cognitive impairment and neuroinflammation in the brain. Using ultraperformance liquid chromatography-mass spectrometry, we performed integrative untargeted metabolomic analysis of metabolite alterations in the serum and hippocampal tissues of amyloid-β (Aβ)-injected AD model mice and sham controls. Multivariate analysis revealed that a

Indexed as

Alzheimer DiseaseBifidobacterium breveAmino AcidsAmyloid beta-PeptidesAnimalsMetabolomeMetabolomicsMiceAmino AcidsAmyloid beta-PeptidesAlzheimer’s diseaseamino acid metabolismBifidobacteriummetabolomics

Identifiers

PMID35215385
PMCPMC8878368
OpenAlexW4211046159

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.