Evidence map›Paper›PMID 35215369›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

A High-Throughput Phenotypic Screen of the 'Pandemic Response Box' Identifies a Quinoline Derivative with Significant Anthelmintic Activity.

Harrison T Shanley, Aya C Taki, Joseph J Byrne, Abdul Jabbar, Tim N C Wells, Kirandeep Samby, Peter R Boag, Nghi Nguyen, Brad E Sleebs, Robin B Gasser

Open access · goldAbstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Advances in Anthelmintic Target Identification.International journal of molecular sciences · 2025
    Review
  7. Article
  8. Evaluation of Serum Supplementation on the Development ofInternational journal of molecular sciences · 2025
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Bioassay-Guided Isolation of Anthelmintic Components fromInternational journal of molecular sciences · 2022
    Article
  16. Thermal proteome profiling revealsFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Harrison T ShanleyDepartment of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-6471-9581
Aya C TakiDepartment of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0003-3489-4367
Joseph J ByrneDepartment of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.
Abdul JabbarDepartment of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-8888-0046
Tim N C WellsMedicines for Malaria Venture (MMV), 1215 Geneva, Switzerland.
Kirandeep SambyMedicines for Malaria Venture (MMV), 1215 Geneva, Switzerland.
Peter R BoagMonash Biomedicine Discovery Institute, Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-0889-0859
Nghi NguyenChemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.
Brad E SleebsChemical Biology Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC 3052, Australia.ORCID 0000-0001-9117-1048
Robin B GasserDepartment of Veterinary Biosciences, Faculty of Veterinary and Agricultural Sciences, The University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-4423-1690
The University of Melbourne · AUMedicines for Malaria Venture · CHWalter and Eliza Hall Institute of Medical Research · AUAustralian Regenerative Medicine Institute · AU

Funding

Australian Research Council LP190101209
6 · The paper itself

Abstract

Parasitic nematodes cause diseases in livestock animals and major economic losses to the agricultural industry worldwide. Nematodes of the order Strongylida, including

Indexed as

anthelminticsCaenorhabditis elegansHaemonchus contortusPandemic Response Boxparasitic nematodephenotypic screeningsmall molecules

Identifiers

PMID35215369
PMCPMC8874578
OpenAlexW4212942259

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.