Evidence map›Paper›PMID 35215303›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Synthesis, Antibacterial Evaluation, and Computational Studies of a Diverse Set of Linezolid Conjugates.

Riham M Bokhtia, Adel S Girgis, Tarek S Ibrahim, Fatma Rasslan, Eman S Nossier, Reham F Barghash, Rajeev Sakhuja, Eatedal H Abdel-Aal, Siva S Panda, Amany M M Al-Mahmoudy

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Design, synthesis, andRSC advances · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Riham M BokhtiaDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.ORCID 0000-0001-5326-7364
Adel S GirgisDepartment of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.
Tarek S IbrahimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.ORCID 0000-0002-3049-4617
Fatma RasslanDepartment of Microbiology and Immunology, Faculty of Pharmacy (Girls), Al Azhar University, Cairo 11651, Egypt.ORCID 0000-0002-6658-1296
Eman S NossierDepartment of Pharmaceutical Medicinal Chemistry and Drug Design, Faculty of Pharmacy (Girls), Al-Azhar University, Cairo 11651, Egypt.ORCID 0000-0001-6159-5333
Reham F BarghashDepartment of Pesticide Chemistry, National Research Centre, Dokki, Giza 12622, Egypt.ORCID 0000-0003-2731-9970
Rajeev SakhujaDepartment of Chemistry, Birla Institute of Technology and Science, Pilani 333031, India.
Eatedal H Abdel-AalDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.
Siva S PandaDepartment of Chemistry and Physics, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3668-104X
Amany M M Al-MahmoudyDepartment of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig 44519, Egypt.

Funding

King Abdulaziz University RG-18-166-41
6 · The paper itself

Abstract

The development of new antibiotics to treat multidrug-resistant (MDR) bacteria or possess broad-spectrum activity is one of the challenging tasks. Unfortunately, there are not many new antibiotics in clinical trials. So, the molecular hybridization approach could be an effective strategy to develop potential drug candidates using the known scaffolds. We synthesized a total of 31 diverse linezolid conjugates

Indexed as

antibacterialconjugateslinezolidpharmacophoreQSAR

Identifiers

PMID35215303
PMCPMC8880098

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.