Evidence map›Paper›PMID 35215266›Full record

ArticlePharmaceuticals (Basel, Switzerland)2022

Exploring Toxins for Hunting SARS-CoV-2 Main Protease Inhibitors: Molecular Docking, Molecular Dynamics, Pharmacokinetic Properties, and Reactome Study.

Mahmoud A A Ibrahim, Alaa H M Abdelrahman, Laila A Jaragh-Alhadad, Mohamed A M Atia, Othman R Alzahrani, Muhammad Naeem Ahmed, Moustafa Sherief Moustafa, Mahmoud E S Soliman, Ahmed M Shawky, Paul W Paré and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Pyronaridine as a Bromodomain-Containing Protein 4-Molecules (Basel, Switzerland) · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Molecules (Basel, Switzerland) · 2023
    Article
  7. Article
  8. ACS omega · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Mahmoud A A IbrahimComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0003-4819-2040
Alaa H M AbdelrahmanComputational Chemistry Laboratory, Chemistry Department, Faculty of Science, Minia University, Minia 61519, Egypt.ORCID 0000-0003-3527-0126
Laila A Jaragh-AlhadadDepartment of Chemistry, Faculty of Science, Kuwait University, Kuwait City 13060, Kuwait.
Mohamed A M AtiaMolecular Genetics and Genome Mapping Laboratory, Genome Mapping Department, Agricultural Genetic Engineering Research Institute (AGERI), Agricultural Research Center (ARC), Giza 12619, Egypt.ORCID 0000-0003-2462-1269
Othman R AlzahraniDepartment of Biology, Faculty of Science, University of Tabuk, Tabuk 71491, Saudi Arabia.ORCID 0000-0002-2726-0473
Muhammad Naeem AhmedDepartment of Chemistry, The University of Azad Jammu and Kashmir, Muzaffarabad 13100, Pakistan.
Moustafa Sherief MoustafaDepartment of Chemistry, Faculty of Science, Kuwait University, Kuwait City 13060, Kuwait.ORCID 0000-0002-3694-5845
Mahmoud E S SolimanMolecular Modelling and Drug Design Research Group, School of Health Sciences, University of KwaZulu-Natal, Westville, Durban 4000, South Africa.
Ahmed M ShawkyScience and Technology Unit (STU), Umm Al-Qura University, Makkah 21955, Saudi Arabia.ORCID 0000-0002-3035-661X
Paul W ParéDepartment of Chemistry & Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0003-1644-723X
Mohamed-Elamir F HegazyChemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Dokki, Giza 12622, Egypt.ORCID 0000-0002-0343-4969
Peter A SidhomDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta 31527, Egypt.

Funding

Science and Technology Development Fund 5480Science and Technology Development Fund 7972
6 · The paper itself

Abstract

The main protease (M

Indexed as

in silico screeningmolecular docking calculationsmolecular dynamics (MD) simulationsreactomeSARS-CoV-2 Mprotoxins

Identifiers

PMID35215266
PMCPMC8875976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.