ArticlePharmaceuticals (Basel, Switzerland)2022
Effects of Salicornia-Based Skin Cream Application on Healthy Humans' Experimental Model of Pain and Itching.
Article in Pharmaceuticals (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Sequential extraction and organosolv pretreatment of halophytes: unlocking biomass recalcitrance for bio-based production.Scientific reports · 2026Article
- Engineering the Rhizosphere Microbiome with Plant Growth Promoting Bacteria for Modulation of the Plant Metabolome.Plants (Basel, Switzerland) · 2024Article
- Phenolic Compounds inMolecules (Basel, Switzerland) · 2023Review
- Harnessing the Value ofMarine drugs · 2023Article
- Bioactive Extracts fromPlants (Basel, Switzerland) · 2023Article
- Diet Supplementation with Polyphenol-RichNutrients · 2022Article
- Overview of the Polyphenols in Salicornia: From Recovery to Health-Promoting Effect.Molecules (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
Halophyte plants are salt-tolerant and are acclimated for growth in saline soils such as along coastal areas. Among the halophytes, the Salicornia species have been used as both folk medicine and functional food for many years due to their high levels of bioactive compounds with supposed anti-inflammatory and antioxidative effects. However, the properties of Salicornia bioactive extracts on pain and itching still remain unclear. In this study, 30 healthy volunteers were randomized to treatments with 10% Salicornia-based cream or placebo cream for 24 or 48 h. On day 0, and 24 or 48 h post cream application, cold/heat detection and pain thresholds, mechanical pain thresholds and sensitivity, trans-epidermal water loss, histamine- and cowhage-evoked itch, and micro-vascular reactivity (neurogenic inflammation) were assessed to evaluate the analgesic, anti-pruritogenic and vasomotor effects. Skin permeability was reduced in the Salicornia-treated area for 48 h compared with 24 h application (
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Registered trials
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