ArticlePathogens (Basel, Switzerland)2022
Engineered Cell Line Imaging Assay Differentiates Pathogenic from Non-Pathogenic Bacteria.
Article in Pathogens (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 5 citations in OpenAlex.
- Fluorescent carbon dot-based biosensor for the rapid and sensitive detection of Escherichia coli DNA.Scientific reports · 2026Article
- Fighting the invader: strategies against intracellular bacteria.Frontiers in pharmacology · 2026Review
- Differentiating Ocular Pathogenic Staphylococcus epidermidis Isolates Using a Human Corneal Epithelial Cell Coculture Model.Translational vision science & technology · 2025Article
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Authors and funding
7 authors at 1 institution in 1 country.
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Abstract
Cell culture systems have greatly expanded our understanding of how bacterial pathogens target signaling pathways to manipulate the host and cause infection. Advances in genetic engineering have allowed for the creation of fluorescent protein readouts within signaling pathways, but these techniques have been underutilized in pathogen biology. Here, we genetically engineered a lung cell line with fluorescent reporters for extracellular signal-related kinase (ERK) and the downstream transcription factor FOS-related antigen 1 (Fra1) and evaluated signaling after inoculation with pathogenic and non-pathogenic bacteria. Cells were inoculated with 100 colony-forming units of
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Registered trials
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