Evidence map›Paper›PMID 35214753›Full record

ArticleVaccines2022

E4orf1 Suppresses

Kotou Sangare, Sabrina Helmold Hait, Madison Moore, Christopher Hogge, Tanya Hoang, Mohammad Arif Rahman, David J Venzon, Celia LaBranche, David Montefiori, Marjorie Robert-Guroff and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kotou SangareDepartment of Biology, Howard University, Washington, DC 20059, USA.
Sabrina Helmold HaitSection on Immune Biology of Retroviral Infection, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Madison MooreDepartment of Biology, Howard University, Washington, DC 20059, USA.
Christopher HoggeSection on Immune Biology of Retroviral Infection, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Tanya HoangSection on Immune Biology of Retroviral Infection, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Mohammad Arif RahmanSection on Immune Biology of Retroviral Infection, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-6120-8943
David J VenzonBiostatistics and Data Management Section, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.ORCID 0000-0002-8990-158X
Celia LaBrancheDuke University Medical Center, Durham, NC 27710, USA.
David MontefioriDuke University Medical Center, Durham, NC 27710, USA.
Marjorie Robert-GuroffSection on Immune Biology of Retroviral Infection, Vaccine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Michael A ThomasDepartment of Biology, Howard University, Washington, DC 20059, USA.ORCID 0000-0003-0134-8765
National Institutes of Health · USDuke Medical Center · USHoward University · US

Funding

Effective Replicating Adenovirus-HIV VaccinesR00AI114379 · NIAID · HOWARD UNIVERSITY · PI THOMAS, MICHAEL A · 2016 to 2017
$498k
National Institute of Allergy and Infectious Diseases R00AI114379NIAID NIH HHS R00 AI114379
6 · The paper itself

Abstract

As demonstrated by the recent COVID pandemic, vaccines can reduce the burden arising from infectious agents. Adenoviruses (Ads) with deletion of the early region 1B55K (ΔE1B Ad) are currently being explored for use in vaccine delivery. Δ

Indexed as

ADCCadenovirusantibodyantibody neutralizationcytokine genesearly region 4 open reading frame 1 (E4orf1)HIVmemory B-cellsnonhuman primatesvaccine

Identifiers

PMID35214753
PMCPMC8875587
OpenAlexW4212825174

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.