Evidence map›Paper›PMID 35214723›Full record

ArticleVaccines2022

Metrics from Wearable Devices as Candidate Predictors of Antibody Response Following Vaccination against COVID-19: Data from the Second TemPredict Study.

Ashley E Mason, Patrick Kasl, Wendy Hartogensis, Joseph L Natale, Stephan Dilchert, Subhasis Dasgupta, Shweta Purawat, Anoushka Chowdhary, Claudine Anglo, Danou Veasna and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 4 institutions in 1 country.

Ashley E MasonOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.ORCID 0000-0002-8744-0185
Patrick KaslHalıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0002-7756-7326
Wendy HartogensisOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Joseph L NataleHalıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA 92093, USA.
Stephan DilchertDepartment of Management, Zicklin School of Business, Baruch College, The City University of New York, New York, NY 10010, USA.ORCID 0000-0001-6733-576X
Subhasis DasguptaSan Diego Supercomputer Center, University of California San Diego, San Diego, CA 92093, USA.
Shweta PurawatSan Diego Supercomputer Center, University of California San Diego, San Diego, CA 92093, USA.
Anoushka ChowdharyOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Claudine AngloOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Danou VeasnaOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Leena S PandyaOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Lindsey M FoxOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Karena Y PuldonOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Jenifer G PratherOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
Amarnath GuptaHalıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA 92093, USA.ORCID 0000-0003-0897-120X
Ilkay AltintasHalıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA 92093, USA.
Benjamin L SmarrHalıcıoğlu Data Science Institute, University of California San Diego, San Diego, CA 92093, USA.
Frederick M HechtOsher Center for Integrative Health, University of California San Francisco, San Francisco, CA 94115, USA.
University of California, San Francisco · USSan Diego Supercomputer Center · USUniversity of California San Diego · USBaruch College · US

Funding

Mentoring and Research in Integrative MedicineK24AT007827 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2013 to 2022
$1.8M
Medical Technology Enterprise Consortium (MTEC) MTEC-20-12-COVID19-D.-023NCCIH NIH HHS K24 AT007827
6 · The paper itself

Abstract

There is significant variability in neutralizing antibody responses (which correlate with immune protection) after COVID-19 vaccination, but only limited information is available about predictors of these responses. We investigated whether device-generated summaries of physiological metrics collected by a wearable device correlated with post-vaccination levels of antibodies to the SARS-CoV-2 receptor-binding domain (RBD), the target of neutralizing antibodies generated by existing COVID-19 vaccines. One thousand, one hundred and seventy-nine participants wore an off-the-shelf wearable device (Oura Ring), reported dates of COVID-19 vaccinations, and completed testing for antibodies to the SARS-CoV-2 RBD during the U.S. COVID-19 vaccination rollout. We found that on the night immediately following the second mRNA injection (Moderna-NIAID and Pfizer-BioNTech) increases in dermal temperature deviation and resting heart rate, and decreases in heart rate variability (a measure of sympathetic nervous system activation) and deep sleep were each statistically significantly correlated with greater RBD antibody responses. These associations were stronger in models using metrics adjusted for the pre-vaccination baseline period. Greater temperature deviation emerged as the strongest independent predictor of greater RBD antibody responses in multivariable models. In contrast to data on certain other vaccines, we did not find clear associations between increased sleep surrounding vaccination and antibody responses.

Indexed as

antibody responsesCOVID-19heart rateheart rate variabilitymRNA vaccinesskin temperaturesleepwearable devices

Identifiers

PMID35214723
PMCPMC8877860
OpenAlexW4211135424

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.