Evidence map›Paper›PMID 35214614›Full record

ArticleVaccines2022

Targeting Secreted Protease/Anti-Protease Balance as a Vaccine Strategy against the Helminth

Krystyna Cwiklinski, Orla Drysdale, Jesús López Corrales, Yolanda Corripio-Miyar, Carolina De Marco Verissimo, Heather Jewhurst, David Smith, Richard Lalor, Tom N McNeilly, John P Dalton

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. In vitro co-culture ofVirulence · 2025
    Article
  3. Article
  4. A Modified Variant ofVaccines · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Krystyna CwiklinskiMolecular Parasitology Laboratory, Centre for One Health, Ryan Institute, National University of Ireland Galway, H91 DK59 Galway, Ireland.
Orla DrysdaleSchool of Biological Sciences, Medical Biology Centre, Queen's University Belfast, Belfast BT9 5DL, UK.
Jesús López CorralesMolecular Parasitology Laboratory, Centre for One Health, Ryan Institute, National University of Ireland Galway, H91 DK59 Galway, Ireland.ORCID 0000-0003-2996-7904
Yolanda Corripio-MiyarMoredun Research Institute, Pentland Science Park, Penicuik, Midlothian EH26 0PZ, UK.ORCID 0000-0002-1344-7405
Carolina De Marco VerissimoMolecular Parasitology Laboratory, Centre for One Health, Ryan Institute, National University of Ireland Galway, H91 DK59 Galway, Ireland.
Heather JewhurstMolecular Parasitology Laboratory, Centre for One Health, Ryan Institute, National University of Ireland Galway, H91 DK59 Galway, Ireland.ORCID 0000-0003-4630-7027
David SmithSchool of Biological Sciences, Medical Biology Centre, Queen's University Belfast, Belfast BT9 5DL, UK.
Richard LalorMolecular Parasitology Laboratory, Centre for One Health, Ryan Institute, National University of Ireland Galway, H91 DK59 Galway, Ireland.
Tom N McNeillyMoredun Research Institute, Pentland Science Park, Penicuik, Midlothian EH26 0PZ, UK.ORCID 0000-0001-6469-0512
John P DaltonMolecular Parasitology Laboratory, Centre for One Health, Ryan Institute, National University of Ireland Galway, H91 DK59 Galway, Ireland.ORCID 0000-0003-3829-9186
Queen's University Belfast · GBMoredun Research Institute · GBOllscoil na Gaillimhe – University of Galway · IE

Funding

European Research Council HELIVAC, 322725Science Foundation Ireland 17/RP/5368Scottish Government Rural Affairs, Food and the Environment Strategic Research Portfolio 2016-2022
6 · The paper itself

Abstract

The liver fluke

Indexed as

Fasciola hepaticaKunitz-type inhibitorprotease-anti-protease balancesheepstefinvaccines

Identifiers

PMID35214614
PMCPMC8878381
OpenAlexW4206942843

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.