Evidence map›Paper›PMID 35214194›Full record

ArticlePharmaceutics2022

Silver Nimesulide Complex in Bacterial Cellulose Membranes as an Innovative Therapeutic Method for Topical Treatment of Skin Squamous Cell Carcinoma.

Tuany Zambroti Candido, Raphael Enoque Ferraz de Paiva, Mariana Cecchetto Figueiredo, Lilian de Oliveira Coser, Silmara Cristina Lazarini Frajácomo, Camilla Abbehausen, Izilda Aparecida Cardinalli, Wilton Rogerio Lustri, João Ernesto Carvalho, Ana Lucia Tasca Gois Ruiz and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Silver, Its Salts and Application in Medicine and Pharmacy.International journal of molecular sciences · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tuany Zambroti CandidoDepartment of Anesthesiology, Oncology and Radiology, Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas 13083-887, SP, Brazil.
Raphael Enoque Ferraz de PaivaInstitute of Chemistry, University of Campinas-UNICAMP, Campinas 13083-970, SP, Brazil.
Mariana Cecchetto FigueiredoPostgraduate Program in Medical Sciences, Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas 13083-887, SP, Brazil.
Lilian de Oliveira CoserDepartment of Clinical Pathology, Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas 13083-887, SP, Brazil.
Silmara Cristina Lazarini FrajácomoDepartment of Biological and Health Sciences, University of Araraquara-UNIARA, Araraquara 14801-320, SP, Brazil.
Camilla AbbehausenInstitute of Chemistry, University of Campinas-UNICAMP, Campinas 13083-970, SP, Brazil.ORCID 0000-0002-8410-2252
Izilda Aparecida CardinalliBoldrini Children's Center, Department of Pathology, Campinas 13083-210, SP, Brazil.
Wilton Rogerio LustriDepartment of Biological and Health Sciences, University of Araraquara-UNIARA, Araraquara 14801-320, SP, Brazil.
João Ernesto CarvalhoFaculty of Pharmaceutical Sciences, University of Campinas-UNICAMP, Campinas 13083-871, SP, Brazil.
Ana Lucia Tasca Gois RuizFaculty of Pharmaceutical Sciences, University of Campinas-UNICAMP, Campinas 13083-871, SP, Brazil.ORCID 0000-0002-0844-8702
Pedro Paulo CorbiInstitute of Chemistry, University of Campinas-UNICAMP, Campinas 13083-970, SP, Brazil.
Carmen Silvia Passos LimaDepartment of Anesthesiology, Oncology and Radiology, Faculty of Medical Sciences, University of Campinas-UNICAMP, Campinas 13083-887, SP, Brazil.ORCID 0000-0002-1314-2345
Universidade Estadual de Campinas (UNICAMP) · BRCentro Universitário de Araraquara · BRCentro Infantil Boldrini · BR

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior 88881.310539/2018-01National Council for Scientific and Technological Development 406444/2018-8, 407012/2018-4National Foundation for the Development of Private Higher Education (FUNADESP) 2700375São Paulo Research Foundation 2015/09833-0, 2016/07729-4, 2017/12719-0, 2018/12062-4, 2018/12590-0
6 · The paper itself

Abstract

Oxidative stress and inflammation act on skin squamous cell carcinoma (SSCC) development and progression. Curative therapy for SSCC patients is mainly based on surgical resection, which can cause various sequelae. Silver ions have in vitro activities over tumor cells, while nimesulide has antioxidant and anti-inflammatory activities. This study aimed to evaluate the effects of a silver(I) complex with nimesulide (AgNMS) incorporated in a sustained release device based on bacterial cellulose membrane, named AgNMS@BCM, on topic SSCC treatment. The antiproliferative effect of AgNMS complex was evaluated in the SCC4, SCC15 and FaDu SCC lines. AgNMS complex activity on exposure of phosphatidylserine (PS) residues and multicaspase activation were evaluated on FaDu cells by flow cytometry. The AgNMS@BCM effects were evaluated in a SSCC model induced by 7,12-dimethylbenzanthracene/12-

Indexed as

antitumor activitybacterial cellulosenimesulidesilverskin carcinomatopical administration

Identifiers

PMID35214194
PMCPMC8877292
OpenAlexW4213216250

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.