Evidence map›Paper›PMID 35214142›Full record

ArticlePharmaceutics2022

Assessment of Nasal-Brain-Targeting Efficiency of New Developed Mucoadhesive Emulsomes Encapsulating an Anti-Migraine Drug for Effective Treatment of One of the Major Psychiatric Disorders Symptoms.

Hadel A Abo El-Enin, Rasha E Mostafa, Marwa F Ahmed, Ibrahim A Naguib, Mohamed A Abdelgawad, Mohammed M Ghoneim, Ebtsam M Abdou

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Hadel A Abo El-EninDepartment of Pharmaceutics, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0003-2030-4231
Rasha E MostafaPharmacology Department, Medical Research and Clinical Studies Institute, National Research Centre, Giza 12622, Egypt.ORCID 0000-0002-5765-350X
Marwa F AhmedDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia.
Ibrahim A NaguibDepartment of Pharmaceutical Chemistry, College of Pharmacy, Taif University, Taif 21944, Saudi Arabia.ORCID 0000-0002-5923-1466
Mohamed A AbdelgawadDepartment of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka 72341, Saudi Arabia.ORCID 0000-0001-9035-5638
Mohammed M GhoneimDepartment of Pharmacy Practice, Faculty of Pharmacy, AlMaarefa University, Ad Diriyah 13713, Saudi Arabia.ORCID 0000-0002-9179-4373
Ebtsam M AbdouDepartment of Pharmaceutics, National Organization of Drug Control and Research (NODCAR), Giza 12622, Egypt.ORCID 0000-0002-1379-8985
Taif University · SAAlmaarefa UniversityJouf University · SANational Organization for Drug Control and Research · EGNational Research Centre · EG

Funding

Deputyship for Research &Innovation, Ministry of Education in Saudi Arabia 1-442-52
6 · The paper itself

Abstract

Migraine is one of the major symptoms of many psychiatric and mental disorders like depression and anxiety. Eletriptan Hydrobromide (EH) is a well-tolerated drug in migraine treatment, but suffers from low oral bioavailability and low brain targeting after oral delivery. New nasal mucoadhesive EH-emulsomes development could be a new means to direct the drug from the nose-to-brain to achieve rapid onset of action and high drug concentration in the brain for acute migraine treatment. Eletriptan mucoadhesive emulsomes formulations were prepared using thin-film hydration method and 2

Indexed as

anti-migrainebrain targetingmucoadhesive emulsomespsychiatric disorders symptoms

Identifiers

PMID35214142
PMCPMC8874718
OpenAlexW4213117238

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.