Evidence map›Paper›PMID 35214116›Full record

ArticlePharmaceutics2022

Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice.

Junya Hanaguri, Noriaki Nagai, Harumasa Yokota, Akifumi Kushiyama, Masahisa Watanabe, Satoru Yamagami, Taiji Nagaoka

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 23 citations in OpenAlex.

  1. Fenofibrate microemulsion eyedrops for treating nitrogen mustard induced corneal injury.Journal of controlled release : official journal of the Controlled Release Society · 2026
    Article
  2. Review
  3. Review
  4. Review
  5. Associations of retinal neurovascular dysfunction with inner retinal layer thickness in non-proliferative diabetic retinopathy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. New Insights into Treating Early and Advanced Stage Diabetic Retinopathy.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Junya HanaguriDepartment of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.
Noriaki NagaiDepartment of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Higashi-Osaka 577-8502, Osaka, Japan.
Harumasa YokotaDepartment of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.ORCID 0000-0003-1878-6032
Akifumi KushiyamaDepartment of Pharmacotherapy, Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.ORCID 0000-0003-1385-7487
Masahisa WatanabeDepartment of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.
Satoru YamagamiDepartment of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.
Taiji NagaokaDepartment of Visual Science, Division of Ophthalmology, Nihon University School of Medicine, Itabashi-ku, Tokyo 173-8610, Japan.ORCID 0000-0003-3933-1002
Nihon University · JPKindai University · JPMeiji Pharmaceutical University · JP

Funding

Grant-in-Aid for Scientific Research from the Ministry of Education, Science, and Culture (C) 26861430
6 · The paper itself

Abstract

We investigated the effect of fenofibrate nano-eyedrops (FenoNano) on impaired retinal blood flow regulation in type 2 diabetic mice. Six-week-old db/db mice were randomly divided into an untreated group (

Indexed as

diabetic retinopathydrug deliveryfenofibrateglial functionnano-eyedropneurovascular coupling

Identifiers

PMID35214116
PMCPMC8876509
OpenAlexW4211245718

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.