Evidence map›Paper›PMID 35214094›Full record

ReviewPharmaceutics2022

Design Principles Governing the Development of Theranostic Anticancer Agents and Their Nanoformulations with Photoacoustic Properties.

Stavroula G Kyrkou, Eirinaios I Vrettos, Dimitris Gorpas, Timothy Crook, Nelofer Syed, Andreas G Tzakos

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stavroula G KyrkouDepartment of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0003-4096-9046
Eirinaios I VrettosDepartment of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-4801-1900
Dimitris GorpasInstitute of Biological and Medical Imaging, Helmholtz Zentrum München, Neuherberg, D-85764 Oberschleißheim, Germany.
Timothy CrookJohn Fulcher Neuro-Oncology Laboratory, Department of Brain Sciences, Division of Neuroscience, Faculty of Medicine, Imperial College London, London W12 0NN, UK.
Nelofer SyedJohn Fulcher Neuro-Oncology Laboratory, Department of Brain Sciences, Division of Neuroscience, Faculty of Medicine, Imperial College London, London W12 0NN, UK.ORCID 0000-0003-1104-5805
Andreas G TzakosDepartment of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0001-6391-0288

Funding

National Hellenic Research Foundation 991
6 · The paper itself

Abstract

The unmet need to develop novel approaches for cancer diagnosis and treatment has led to the evolution of theranostic agents, which usually include, in addition to the anticancer drug, an imaging agent based mostly on fluorescent agents. Over the past few years, a non-invasive photoacoustic imaging modality has been effectively integrated into theranostic agents. Herein, we shed light on the design principles governing the development of theranostic agents with photoacoustic properties, which can be formulated into nanocarriers to enhance their potency. Specifically, we provide an extensive analysis of their individual constituents including the imaging dyes, drugs, linkers, targeting moieties, and their formulation into nanocarriers. Along these lines, we present numerous relevant paradigms. Finally, we discuss the clinical relevance of the specific strategy, as also the limitations and future perspectives, and through this review, we envisage paving the way for the development of theranostic agents endowed with photoacoustic properties as effective anticancer medicines.

Indexed as

cancernanoformulationsphotoacousticphototherapytheranostics

Identifiers

PMID35214094
PMCPMC8877540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.