Evidence map›Paper›PMID 35214058›Full record

ArticlePharmaceutics2022

Amphiphilic Anionic Oligomer-Stabilized Calcium Phosphate Nanoparticles with Prospects in siRNA Delivery via Convection-Enhanced Delivery.

Franziska Mitrach, Maximilian Schmid, Magali Toussaint, Sladjana Dukic-Stefanovic, Winnie Deuther-Conrad, Heike Franke, Alexander Ewe, Achim Aigner, Christian Wölk, Peter Brust and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Franziska MitrachInstitute of Pharmacy, Pharmaceutical Technology, Medical Faculty, University of Leipzig, Eilenburger Straße 15A, 04317 Leipzig, Germany.ORCID 0000-0003-4518-8054
Maximilian SchmidInstitute of Pharmacy, Pharmaceutical Technology, Medical Faculty, University of Leipzig, Eilenburger Straße 15A, 04317 Leipzig, Germany.
Magali ToussaintDepartment of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf, Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0002-1136-3857
Sladjana Dukic-StefanovicDepartment of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf, Permoserstraße 15, 04318 Leipzig, Germany.
Winnie Deuther-ConradDepartment of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf, Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0003-3168-3062
Heike FrankeRudolf-Boehm-Institute for Pharmacology and Toxicology, Faculty of Medicine, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0001-7126-6146
Alexander EweRudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0002-8252-1605
Achim AignerRudolf-Boehm-Institute for Pharmacology and Toxicology, Clinical Pharmacology, Faculty of Medicine, University of Leipzig, 04107 Leipzig, Germany.ORCID 0000-0002-2778-6256
Christian WölkInstitute of Pharmacy, Pharmaceutical Technology, Medical Faculty, University of Leipzig, Eilenburger Straße 15A, 04317 Leipzig, Germany.ORCID 0000-0002-8067-7307
Peter BrustDepartment of Neuroradiopharmaceuticals, Helmholtz-Zentrum Dresden-Rossendorf, Permoserstraße 15, 04318 Leipzig, Germany.ORCID 0000-0001-5555-7058
Michael C HackerInstitute of Pharmacy, Pharmaceutical Technology, Medical Faculty, University of Leipzig, Eilenburger Straße 15A, 04317 Leipzig, Germany.ORCID 0000-0002-4776-2294
Michaela Schulz-SiegmundInstitute of Pharmacy, Pharmaceutical Technology, Medical Faculty, University of Leipzig, Eilenburger Straße 15A, 04317 Leipzig, Germany.ORCID 0000-0003-1340-1850
Leipzig University · DEHelmholtz-Zentrum Dresden-Rossendorf · DEHeinrich Heine University Düsseldorf · DE

Funding

Deutsche Forschungsgemeinschaft 59307082Development Bank of Saxony 100327676
6 · The paper itself

Abstract

Convection-enhanced delivery (CED) has been introduced as a concept in cancer treatment to generate high local concentrations of anticancer therapeutics and overcome the limited diffusional distribution, e.g., in the brain. RNA interference provides interesting therapeutic options to fight cancer cells but requires nanoparticulate (NP) carriers with a size below 100 nm as well as a low zeta potential for CED application. In this study, we investigated calcium phosphate NPs (CaP-NPs) as siRNA carriers for CED application. Since CaP-NPs tend to aggregate, we introduced a new terpolymer (o14PEGMA(1:1:2.5) NH

Indexed as

calcium phosphate nanoparticlescell transfectionparticle characterizationPEGylated terpolymersiRNA delivery

Identifiers

PMID35214058
PMCPMC8877163
OpenAlexW4210490027

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.