Evidence map›Paper›PMID 35214044›Full record

ArticlePharmaceutics2022

Theranostic Microbubbles with Homogeneous Ligand Distribution for Higher Binding Efficacy.

Simone A G Langeveld, Bram Meijlink, Inés Beekers, Mark Olthof, Antonius F W van der Steen, Nico de Jong, Klazina Kooiman

Abstract read
In one paragraph

Article in Pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Simone A G LangeveldThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-7604-3013
Bram MeijlinkThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Inés BeekersThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Mark OlthofThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Antonius F W van der SteenThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.
Nico de JongThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0001-8902-0099
Klazina KooimanThorax Center, Biomedical Engineering, Erasmus University Medical Center Rotterdam, 3000 CA Rotterdam, The Netherlands.ORCID 0000-0002-0607-4989

Funding

Dutch Research Council 17543Phospholipid Research Center KKO-2017-057/1-1Thorax Center of Erasmus University Medical Center in Rotterdam not applicable
6 · The paper itself

Abstract

Phospholipid-coated targeted microbubbles are used for ultrasound molecular imaging and locally enhanced drug delivery, with the binding efficacy being an important trait. The use of organic solvent in microbubble production makes the difference between a heterogeneous or homogeneous ligand distribution. This study demonstrates the effect of ligand distribution on the binding efficacy of phospholipid-coated α

Indexed as

binding efficacyligand distributionphospholipid-coated microbubblestargeted drug deliveryultrasound molecular imaging

Identifiers

PMID35214044
PMCPMC8878664

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.