Evidence map›Paper›PMID 35213767›Full record

ArticleChemistry & biodiversity2022

Isolation of Thioinosine and Butenolides from a Terrestrial Actinomycetes sp. GSCW-51 and Their in Silico Studies for Potential against SARS-CoV-2.

Mamona Nazir, Muhammad Imran Tousif, Muhammad Khalid, Shehla Parveen, Naseem Akhter, Nosheen Farooq, Muhammad Usman Khan, Rana Farhat Mehmood, Mohamad Fawzi Mahomoodally, Shabbir Muhammad and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mamona NazirDepartment of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan.
Muhammad Imran TousifDepartment of Chemistry, Division of Science and Technology, University of Education Lahore, Lahore, 32200, Pakistan.ORCID http://orcid.org/0000-0002-5777-6112
Muhammad KhalidDepartment of Chemistry, Khwaja Fareed University of Engineering & Information Technology, Rahim Yar Khan, 64200, Pakistan.
Shehla ParveenDepartment of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan.
Naseem AkhterDepartment of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan.
Nosheen FarooqDepartment of Chemistry, Government Sadiq College Women University, Bahawalpur, 63100, Pakistan.
Muhammad Usman KhanDepartment of Chemistry, University of Okara, Okara, 56300, Pakistan.
Rana Farhat MehmoodDepartment of Chemistry, Division of Science and Technology, University of Education Lahore, Lahore, 32200, Pakistan.
Mohamad Fawzi MahomoodallyDepartment of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, 230, Réduit, Mauritius.
Shabbir MuhammadDepartment of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.
Saleh S AlarfajiDepartment of Chemistry, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.

Funding

German Academic Exchange Program (DAAD), GermanyHEC Pakistan SRGP 1543King Abdullah University of Science & Technology (KAUST) in Thuwal, Saudi ArabiaKing Khalid University RGP.2/156/42
6 · The paper itself

Abstract

In our continuous screening for bioactive microbial natural products, the culture extracts of a terrestrial Actinomycetes sp. GSCW-51 yielded two new metabolites, i. e., 5-hydroxymethyl-3-(1-hydroxy-6-methyl-7-oxooctyl)dihydrofuran-2(3H)-one (1), 5-hydroxymethyl-3-(1,7-dihydroxy-6-methyloctyl)dihydrofuran-2(3H)-one (2), and two known compounds; 5'-methylthioinosine (3), and 5'-methylthioinosine sulfoxide (4), which are isolated first time from any natural source, along with four known compounds (5-8). The structures of the new compounds were deduced by HR-ESI-MS, 1D and 2D NMR data, and in comparison with related compounds from the literature. Additionally, owing to the current COVID-19 pandemic situation, we also computationally explored the therapeutic potential of our isolated compounds against SARS-CoV-2. Compound 4 showed the best binding energies of -6.2 and -6.6 kcal/mol for M

Indexed as

COVID-19 Drug TreatmentSARS-CoV-2ActinomycesHumansMolecular Docking SimulationMolecular Dynamics SimulationPandemicsThioinosineThioinosinebutenolidesCOVID-19in silico studystructure elucidationTerrestrial Actinomycetesthioinosine

Identifiers

PMID35213767
PMCPMC9074031

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.