ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
The apathy, gait impairment, and executive dysfunction (AGED) triad vascular variant.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Early identification of vascular cognitive impairment from a multimodal perspective: a combined diagnosis from targeted cognitive assessments, imaging biomarkers, and molecular fluid biomarkers to ecological behavioral characteristics.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Blood flow in the human cerebral cortex: Large-scale pial vascularization and 1D simulation.PLoS computational biology · 2025Article
- Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease.Brain : a journal of neurology · 2024Article
- Association between behavioral and psychological symptoms and cerebral small vessel disease MRI findings in memory clinic patients.Frontiers in aging neuroscience · 2023Article
- The apathy, gait impairment, and executive dysfunction (AGED) triad vascular variant.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Article
- Detecting apathy in patients with cerebral small vessel disease.Frontiers in aging neuroscience · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Apathy, gait disturbances, and executive dysfunction (AGED) often occur together. Although they can arise independently, the presence of one might portend another. This recognition suggests the possible etiology. We focus on the most common, the vascular. We explain the AGED vascular mechanism through the ambibaric brain concept. The brain contains two complementary blood pressure systems: One high in the primitive brain (brainstem, basal ganglia, and thalamus) and a low-pressure system in the Homo sapiens brain (cerebral hemispheres). Hypertension inflicts the most damage on the primitive brain. The frontal systems connect to the basal ganglia, then the thalamus and back to the cortex. Many connections converge on the primitive brain where they are damaged by vascular disease. We need methods of determining optimal, individual blood pressures. Although the AGED triad can result from other causes, it should first signal a vascular etiology, the most prevalent, treatable, and preventable one.
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