Evidence map›Paper›PMID 35213665›Full record

SynthesisPloS one2022

Comparison of mean platelet volume (MPV) and red blood cell distribution width (RDW) between psoriasis patients and controls: A systematic review and meta-analysis.

Ping Yi, Jiao Jiang, Zheyu Wang, Xing Wang, Mingming Zhao, Haijing Wu, Yan Ding

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Ping YiDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Jiao JiangDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zheyu WangDepartment of Dermatology, Hainan General Hospital, Haikou, Hainan, China.ORCID 0000-0003-3376-8422
Xing WangDepartment of Neurosurgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Mingming ZhaoDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Haijing WuDepartment of Dermatology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yan DingDepartment of Dermatology, Hainan Provincial Hospital of Skin Disease, Haikou, Hainan, China.
Central South University · CNHainan General Hospital · CNHainan Provincial Hospital of Traditional Chinese Medicine · CNSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe predictive role of hematological indexes of mean platelet volume (MPV) and red cell distribution width (RDW) has been demonstrated in cardiovascular disease concomitant with psoriasis. This meta-analysis is intended to assess whether MPV and RDW can also serve as biomarkers for the early diagnosis and disease severity assessment of psoriasis. MATERIAL AND

methods13 studies which enrolled 1331 psoriasis patients and 919 healthy volunteers were included after screening the search results from PubMed, Embase and the Cochrane Library since inception to Mar 14, 2020. MPV of psoriasis participants and their counterparts was assessed in 10 studies, and RDW was evaluated in 4 studies, while the disease severity was measured by the Psoriasis Area and Severity Index (PASI) in 11 studies. Random-effect model analysis was applied to calculate pooled standard mean difference (SMD) with 95% confidence interval (95% CI).

resultsAssociations of MPV and RDW with the presence of psoriasis were demonstrated (MPV: SMD = 0.503, 95% CI: 0.242-0.765; RDW: SMD = 0.522, 95% CI: 0.228-0.817), but no statistically significant correlation of MPV and disease severity of psoriasis was found in meta-regression analysis (p = 0.208). Subgroup analysis revealed that the diagnosis value of MPV and RDW was consistent regardless of PASI and study type. Heterogeneity analysis between studies was implemented by chi-squared test and I2 statistics. Begg's and Egger's test were utilized for the evaluation of publication bias. The sensitivity analysis revealed no significant alteration no matter which study was excluded.

conclusionMPV and RDW could serve as promising predictive diagnostic biomarkers of psoriasis.

Indexed as

Erythrocyte IndicesMean Platelet VolumeBiomarkersCase-Control StudiesDatabases, FactualHumansPsoriasisSeverity of Illness IndexBiomarkers

Identifiers

PMID35213665
PMCPMC8880915
OpenAlexW4214674264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.