Evidence map›Paper›PMID 35213298›Full record

ReviewAmerican journal of respiratory and critical care medicine2022

Extracorporeal Membrane Oxygenation during Respiratory Pandemics: Past, Present, and Future.

Daniel Brodie, Darryl Abrams, Graeme MacLaren, Crystal E Brown, Laura Evans, Ryan P Barbaro, Carolyn S Calfee, Catherine L Hough, Jo-Anne Fowles, Christian Karagiannidis and 2 more

Abstract readReview
In one paragraph

Review in American journal of respiratory and critical care medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Article
  3. A compact machine perfusion device for whole blood perfusion in isolated rat liver.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025
    Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Review
  11. Discontinuation of ECMO-a review with a note on Indian scenario.Indian journal of thoracic and cardiovascular surgery · 2023
    Review
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Daniel BrodieColumbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, New York, New York.
Darryl AbramsColumbia University College of Physicians and Surgeons/New York-Presbyterian Hospital, New York, New York.ORCID 0000-0001-9073-3897
Graeme MacLarenCardiothoracic Intensive Care Unit, Department of Cardiac, Thoracic, and Vascular Surgery, National University Health System, Singapore, Singapore.
Crystal E BrownDivision of Pulmonary, Critical Care, and Sleep Medicine, Harborview Medical Center, and.
Laura EvansDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington, Seattle, Washington.
Ryan P BarbaroDivision of Pediatric Critical Care Medicine, University of Michigan, Ann Arbor, Michigan.
Carolyn S CalfeeDivision of Pulmonary, Critical Care, Allergy, and Sleep Medicine, Department of Medicine, University of California San Francisco, San Francisco, California.
Catherine L HoughDivision of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, Oregon Health and Science University, Portland, Oregon.
Jo-Anne FowlesIntensive Care, Division of Surgery, Transplant and Anaesthetics, Royal Papworth Hospital NHS Foundation Trust, Cambridge, United Kingdom.
Christian KaragiannidisARDS and ECMO Center Cologne-Merheim, Witten/Herdecke University, Cologne, Germany.
Arthur S SlutskyInterdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Alain CombesSorbonne University, INSERM, UMRS1166-ICAN, Institute of Cardiometabolism and Nutrition, Paris, France; and.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of extracorporeal membrane oxygenation (ECMO) in the management of severe acute respiratory failure, including acute respiratory distress syndrome, has become better defined in recent years in light of emerging high-quality evidence and technological advances. Use of ECMO has consequently increased throughout many parts of the world. The coronavirus disease (COVID-19) pandemic, however, has highlighted deficiencies in organizational capacity, research capability, knowledge sharing, and resource use. Although governments, medical societies, hospital systems, and clinicians were collectively unprepared for the scope of this pandemic, the use of ECMO, a highly resource-intensive and specialized form of life support, presented specific logistical and ethical challenges. As the pandemic has evolved, there has been greater collaboration in the use of ECMO across centers and regions, together with more robust data reporting through international registries and observational studies. Nevertheless, centralization of ECMO capacity is lacking in many regions of the world, and equitable use of ECMO resources remains uneven. There are no widely available mechanisms to conduct large-scale, rigorous clinical trials in real time. In this critical care review, we outline lessons learned during COVID-19 and prior respiratory pandemics in which ECMO was used, and we describe how we might apply these lessons going forward, both during the ongoing COVID-19 pandemic and in the future.

Indexed as

COVID-19Extracorporeal Membrane OxygenationRespiratory Distress SyndromeHumansPandemicsSARS-CoV-2acute respiratory distress syndromeCOVID-19ECMOextracorporeal circulationrespiratory failure

Identifiers

PMID35213298
PMCPMC9875895

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.