Evidence map›Paper›PMID 35213229›Full record

ArticleScience advances2022

The chaperone Tsr2 regulates Rps26 release and reincorporation from mature ribosomes to enable a reversible, ribosome-mediated response to stress.

Yoon-Mo Yang, Katrin Karbstein

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
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  9. Article
  10. Neuronal processes contain the essential components for the late steps of ribosome biogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Specialized ribosomes: integrating new insights and current challenges.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  13. Remodelled ribosomal populations synthesize a specific proteome in proliferating plant tissue during cold.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  14. Ribosome heterogeneity and specialization.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Ribosome Structural Changes Dynamically Affect Ribosome Function.International journal of molecular sciences · 2024
    Review
  20. Ribosome Assembly and Repair.Annual review of cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Yoon-Mo YangDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0001-5329-2236
Katrin KarbsteinDepartment of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL 33458, USA.ORCID 0000-0002-4034-1331
Scripps Research Institute · US

Funding

Dissecting the Mechanisms of Regulation and Quality Control in Ribosome Assembly and the Consequences of their FailureR35GM136323 · NIGMS · VANDERBILT UNIVERSITY · PI Katrin Karbstein · 2020 to 2026
$6.1M
Quality Control in Ribosome Assembly - the Function of Regulatory ProteinsR01GM086451 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KARBSTEIN, KATRIN · 2009 to 2019
$4.8M
Kinase-mediated assembly of the mRNA entry channel in 40S ribosomesR01GM117093 · NIGMS · SCRIPPS FLORIDA · PI KARBSTEIN, KATRIN · 2016 to 2019
$1.7M
Unraveling the mechanism by which Rps26-deficient ribosomes form to support the stress responseF32GM139302 · NIGMS · UNIVERSITY OF FLORIDA · PI YANG, JASON YOON-MO · 2020 to 2021
$134k
NIGMS NIH HHS F32 GM139302NIGMS NIH HHS R01 GM086451NIGMS NIH HHS R01 GM117093NIGMS NIH HHS R35 GM136323
6 · The paper itself

Abstract

Although ribosome assembly is quality controlled to maintain protein homeostasis, different ribosome populations have been described. How these form, especially under stress conditions that affect energy levels and stop the energy-intensive production of ribosomes, remains unknown. Here, we demonstrate how a physiologically relevant ribosome population arises during high Na

Identifiers

PMID35213229
PMCPMC8880767
OpenAlexW4220856243

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.