Evidence map›Paper›PMID 35213226›Full record

ArticleScience advances2022

Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets.

Marc A Fernandez-Yague, Lauren A Hymel, Claire E Olingy, Claire McClain, Molly E Ogle, José R García, Dustin Minshew, Sofiya Vyshnya, Hong Seo Lim, Peng Qiu and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 33 citations in OpenAlex.

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  14. Bottom-up synthetic immunology.Nature nanotechnology · 2024
    Review
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  17. Article
  18. Article
  19. Pyroptosis in bone loss.Apoptosis : an international journal on programmed cell death · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Marc A Fernandez-YagueThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0002-4062-8906
Lauren A HymelThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0002-6749-8486
Claire E OlingyThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0002-4449-4319
Claire McClainThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0002-3393-2379
Molly E OgleThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
José R GarcíaPetit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.
Dustin MinshewThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.
Sofiya VyshnyaThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0001-8713-9803
Hong Seo LimThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0002-3641-231X
Peng QiuThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0003-3256-0734
Andrés J GarcíaPetit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA, USA.ORCID 0000-0001-6602-2518
Edward A BotchweyThe Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA, USA.ORCID 0000-0003-1140-5786
Georgia Institute of Technology · US

Funding

Research Training Program Plan on Cell and Tissue Engineering (CTEng)T32GM008433 · NIGMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 1991 to 2021
$7.1M
Hydrogels for hMSC delivery & engraftmentR01AR062368 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2022
$3.5M
Osseo-reparative, integrin-specific materialsR01AR062920 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2012 to 2021
$3.2M
Mechanosensing at Focal AdhesionsR01EB024322 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI GARCIA, ANDRES J · 2018 to 2022
$1.3M
Immune Modulatory Nanofibers for Skeletal Muscle ReconstructionR56AR071708 · NIAMS · GEORGIA INSTITUTE OF TECHNOLOGY · PI BOTCHWEY, EDWARD A. · 2017 to 2018
$789k
Regenerative Immunotherapy using light triggered in vivo activation of adhesive peptidesR56DE029703 · NIDCR · GEORGIA INSTITUTE OF TECHNOLOGY · PI BOTCHWEY, EDWARD A., GARCIA, ANDRES J · 2020 to 2020
$430k
NIAMS NIH HHS R01 AR062368NIAMS NIH HHS R01 AR062920NIAMS NIH HHS R56 AR071708NIBIB NIH HHS R01 EB024322NIDCR NIH HHS R56 DE029703NIGMS NIH HHS T32 GM008433
6 · The paper itself

Abstract

Understanding the immune response to hydrogel implantation is critical for the design of immunomodulatory biomaterials. To study the progression of inflammation around poly(ethylene glycol) hydrogels presenting Arg-Gly-Asp (RGD) peptides and vascular endothelial growth factor, we used temporal analysis of high-dimensional flow cytometry data paired with intravital imaging, immunohistochemistry, and multiplexed proteomic profiling. RGD-presenting hydrogels created a reparative microenvironment promoting CD206

Indexed as

HydrogelsVascular Endothelial Growth Factor ABiocompatible MaterialsCluster AnalysisCytokinesImmunityOligopeptidesProteomicsBiocompatible MaterialsCytokinesHydrogelsOligopeptidesVascular Endothelial Growth Factor A

Identifiers

PMID35213226
PMCPMC8880784
OpenAlexW4214770922

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.