Evidence map›Paper›PMID 35213156›Full record

ArticleThe journal of physical chemistry. A2022

X-ray Induced Fragmentation of Protonated Cystine.

Geethanjali Gopakumar, Pamela H W Svensson, Oscar Grånäs, Barbara Brena, Lucas Schwob, Isaak Unger, Clara-Magdalena Saak, Martin Timm, Christine Bülow, Markus Kubin and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physical chemistry. A, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Geethanjali GopakumarDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0001-6790-3157
Pamela H W SvenssonDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.
Oscar GrånäsDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.
Barbara BrenaDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0003-0503-4691
Lucas SchwobDeutsches Elektronen-Synchrotron DESY, Notkestrasse 85, DE-22607 Hamburg, Germany.ORCID https://orcid.org/0000-0002-4274-365X
Isaak UngerDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0003-1001-4134
Clara-Magdalena SaakDepartment of Physical Chemistry, University of Vienna, Währingerstraßze 42, 1090 Vienna, Austria.ORCID https://orcid.org/0000-0001-7898-0713
Martin TimmAbteilung für Hochempfindliche Röntgenspektroskopie, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Strasse 15, DE-12489 Berlin, Germany.
Christine BülowAbteilung für Hochempfindliche Röntgenspektroskopie, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Strasse 15, DE-12489 Berlin, Germany.
Markus KubinAbteilung für Hochempfindliche Röntgenspektroskopie, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Strasse 15, DE-12489 Berlin, Germany.ORCID https://orcid.org/0000-0002-2209-9385
Vicente Zamudio-BayerAbteilung für Hochempfindliche Röntgenspektroskopie, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Strasse 15, DE-12489 Berlin, Germany.ORCID https://orcid.org/0000-0002-4038-0584
J Tobias LauAbteilung für Hochempfindliche Röntgenspektroskopie, Helmholtz-Zentrum Berlin für Materialien und Energie, Albert-Einstein-Strasse 15, DE-12489 Berlin, Germany.ORCID https://orcid.org/0000-0003-0976-6902
Bernd von IssendorffPhysikalisches Institut, Albert-Ludwigs-Universität Freiburg, Hermann-Herder-Strasse 3, DE-79104 Freiburg, Germany.
Abdul R AbidDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.
Andreas LindbladDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0002-9188-9604
Emma DanielssonDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.
Ebba KoerferDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.
Carl CalemanDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0003-2638-1940
Olle BjörneholmDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0002-7307-5404
Rebecka LindbladDepartment of Physics and Astronomy, Uppsala University, Box 516, SE-751 20 Uppsala, Sweden.ORCID https://orcid.org/0000-0001-6162-1167

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We demonstrate site-specific X-ray induced fragmentation across the sulfur L-edge of protonated cystine, the dimer of the amino acid cysteine. Ion yield NEXAFS were performed in the gas phase using electrospray ionization (ESI) in combination with an ion trap. The interpretation of the sulfur L-edge NEXAFS spectrum is supported by Restricted Open-Shell Configuration Interaction (ROCIS) calculations. The fragmentation pathway of triply charged cystine ions was modeled by Molecular Dynamics (MD) simulations. We have deduced a possible pathway of fragmentation upon excitation and ionization of S 2p electrons. The disulfide bridge breaks for resonant excitation at lower photon energies but remains intact upon higher energy resonant excitation and upon ionization of S 2p. The larger fragments initially formed subsequently break into smaller fragments.

Indexed as

CysteineCystineElectronsIonsSpectrometry, Mass, Electrospray IonizationX-RaysCysteineCystineIons

Identifiers

PMID35213156
PMCPMC8919253

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.