ArticleMethods in molecular biology (Clifton, N.J.)2022
Conjugation of Nucleic Acids and Drugs to Gold Nanoparticles.
Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Biosynthesis of silver and gold nanoparticles usingBiomedical reports · 2026Article
- Linear Polyethyleneimine-Coated Gold Nanoparticles as a Platform for Central Nervous System Targeting.Polymers · 2026Article
- Aptamer-conjugated gold nanoparticles enable oligonucleotide delivery into muscle stem cells to promote regeneration of dystrophic muscles.Nature communications · 2025Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gold nanoparticles (AuNPs) can be used as carriers for biomolecules or drugs in cell culture and animal models. Particularly, AuNPs ease their internalization into the cell and prevent their degradation. In addition, engineered AuNPs can be employed as sensors of a variety of biomarkers, where the electronic and optical properties of the AuNPs are exploited for a convenient, easy, and fast read out. However, in all these applications, a key step requires the conjugation of the different molecules to the nanoparticles. The most common approach exploits the great affinity of sulfur for gold. Herein, we summarize the methods used by our group for the conjugation of different molecules with AuNPs. The procedure is easy and takes around 2 days, where the reagents are slowly added, following an incubation at room temperature to ensure the complete conjugation. Finally, the unbound material is removed by centrifugation.
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