Evidence map›Paper›PMID 35212911›Full record

ArticleEuropean geriatric medicine2022

Sarcopenia reduces quality of life in the long-term: longitudinal analyses from the English longitudinal study of ageing.

Nicola Veronese, Ai Koyanagi, Emanuele Cereda, Stefania Maggi, Mario Barbagallo, Ligia J Dominguez, Lee Smith

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European geriatric medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 9 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 9 syntheses or guidelines pooled it, 76 citations in OpenAlex.

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  4. A systematic review of quality of life (QoL) studies using the CASP scale in older adults.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2024
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  11. Effect of calcifediol and cholecalciferol on muscle function in postmenopausal women: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Nicola VeroneseGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, via del Vespro, 141, 90127, Palermo, Italy. nicola.veronese@unipa.it.
Ai KoyanagiResearch and Development Unit, Parc Sanitari Sant Joan de Déu, CIBERSAM, Dr. Antoni Pujadas, 42, 08830, Sant Boi de Llobregat, Barcelona, Spain.
Emanuele CeredaClinical Nutrition and Dietetics Unit, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy.
Stefania MaggiInstitute of Neuroscience, National Research Council, Padova, Italy.
Mario BarbagalloGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, via del Vespro, 141, 90127, Palermo, Italy.
Ligia J DominguezGeriatric Unit, Department of Internal Medicine and Geriatrics, University of Palermo, via del Vespro, 141, 90127, Palermo, Italy.
Lee SmithCentre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, UK.
University of Palermo · ITAnglia Ruskin University · GBInstitució Catalana de Recerca i Estudis Avançats · ESNational Research Council · ITPoliclinico San Matteo Fondazione · IT

Funding

Socioeconomic gradient in CHD in early old ageR01HL036310 · NHLBI · UNIVERSITY OF LONDON · PI KIVIMAKI, MIKA J, MARMOT, MICHAEL G · 1986 to 2012
$3.1M
Health behaviors over the adult lifecourse and cognitive agingR01AG034454 · NIA · UNIVERSITY COLLEGE LONDON · PI KIVIMAKI, MIKA J, SINGH-MANOUX, ARCHANA · 2009 to 2013
$1.5M
Medical Research Council K013351Medical Research Council MR/KO232331/1NHLBI NIH HHS R01 HL036310NIA NIH HHS R01 AG034454Wellcome TrustWellcome Trust WT087640MA
6 · The paper itself

Abstract

purposeMixed findings exist for sarcopenia/quality of life (QoL) relationship. Moreover, the majority of studies in this area have utilized a cross-sectional design or specific clinical populations. Therefore, the aim of the present study was to examine the association between sarcopenia at baseline and QoL at 10 years follow-up in a large representative sample of older English adults.

methodsSarcopenia was diagnosed as having low handgrip strength and low skeletal muscle mass index. QoL was measured using the CASP (control, autonomy, self-realisation and pleasure)-19, with higher values reflecting higher QoL. Multivariable logistic regression analysis was conducted to assess prospective associations between sarcopenia at baseline and poor QoL at follow-up; generalized linear model with repeated measures was used for reporting mean changes during follow-up between sarcopenia and not.

resultsAmong 4044 older participants initially included at baseline (mean age: 70.7 years; 55.1% females), 376 had sarcopenia. In the multivariable analysis, after adjusting for several potential confounders, sarcopenia at baseline was associated with a higher incidence of poor QoL (odds ratio, OR = 5.82; 95% confidence interval, CI 3.45-9.82). After matching for QoL values at baseline and adjusting for potential confounders, people with sarcopenia reported significantly lower values in CASP-19 (mean difference = - 3.94; 95% CI - 4.77 to - 3.10).

conclusionsIn this large representative sample of older English adults, it was observed that sarcopenia at baseline was associated with worse scores of QoL at follow-up compared to those without sarcopenia at baseline. It may be prudent to target those with sarcopenia to improve QoL.

Indexed as

SarcopeniaAgedAgingCross-Sectional StudiesFemaleHand StrengthHumansLongitudinal StudiesMaleQuality of LifeAgeingELSAEpidemiologyLongitudinalOlder adultsQuality of lifeSarcopenia

Identifiers

PMID35212911
PMCPMC9151534
OpenAlexW4214769471

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.