Evidence map›Paper›PMID 35212909›Full record

ArticleObesity surgery2022

Bariatric Surgery and Breast Cancer Incidence: a Population-Based, Matched Cohort Study.

Aristithes G Doumouras, Olivia Lovrics, J Michael Paterson, Rinku Sutradhar, Lawrence Paszat, Branavan Sivapathasundaram, Jean-Eric Tarride, Mehran Anvari

Abstract read
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In one paragraph

Article in Obesity surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Aristithes G DoumourasDivision of General Surgery, McMaster University, Hamilton, ON, L8V 1C3, Canada.
Olivia LovricsDivision of General Surgery, McMaster University, Hamilton, ON, L8V 1C3, Canada.
J Michael PatersonICES, Toronto, ON, M4N 3M5, Canada.
Rinku SutradharICES, Toronto, ON, M4N 3M5, Canada.
Lawrence PaszatICES, Toronto, ON, M4N 3M5, Canada.
Branavan SivapathasundaramICES, Toronto, ON, M4N 3M5, Canada.
Jean-Eric TarrideDepartment of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, ON, L8S 4K1, Canada.
Mehran AnvariDivision of General Surgery, McMaster University, Hamilton, ON, L8V 1C3, Canada. anvari@mcmaster.ca.ORCID 0000-0001-7256-5789
University of Toronto · CAImpact · CAMcMaster University · CAPrograms for Assessment of Technology in Health Research Institute · CASt. Joseph’s Healthcare Hamilton · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeObesity is associated with increased breast cancer risk in women. Bariatric surgery induces substantial weight loss. However, the effects of such weight loss on subsequent breast cancer risk in women with obesity are poorly understood. To examine breast cancer incidence and related outcomes in women with obesity undergoing bariatric surgery. MATERIALS AND

methodsThis was a population-based matched cohort study of breast surgery outcomes utilizing linked clinical databases in Ontario, Canada. Women with obesity who underwent bariatric surgery were 1:1 matched using a propensity score to non-surgical controls for age and breast cancer screening history. The main outcomes were incidence of breast cancer after lag periods of 1, 2, and 5 years. Additional outcomes included tumor hormone receptor status, cancer stage, and treatments undertaken. Time-varying Cox proportional hazard models accounting for screening during follow-up were used to model cancer incidence.

resultsA total of 12,724 women per group were included, average age 45.09. After a 1-year lag, breast cancer incidence occurred in 1.09% and 0.79% of the control and surgery groups, respectively (adjusted hazard ratio, 0.81 [95%CI 0.69-0.95]; p = 0.01). This association was maintained after lag periods of 2 and 5 years. Women in the surgical cohort diagnosed with breast cancer were more likely to have low-grade tumors and less likely to have high-grade tumors (overall p < 0.01). No association was found for tumor hormone receptor status, although the surgical group was more likely to have her2neu-negative tumors (p = 0.01).

conclusionBariatric surgery was associated with a lower incidence of breast cancer and lower tumor grade in women with obesity. Further evaluation of outcomes, including mortality, is required.

Indexed as

Bariatric SurgeryBreast NeoplasmsObesity, MorbidCohort StudiesFemaleHormonesHumansIncidenceMiddle AgedObesityOntarioRetrospective StudiesWeight LossHormonesBariatric surgeryBreast cancerCancer incidenceWeight loss

Identifiers

PMID35212909
OpenAlexW4214656942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.