Evidence map›Paper›PMID 35212821›Full record

GuidelineSurgical endoscopy2022

UEG and EAES rapid guideline: Systematic review, meta-analysis, GRADE assessment and evidence-informed European recommendations on TaTME for rectal cancer.

Marco Milone, Michel Adamina, Alberto Arezzo, Nona Bejinariu, Luigi Boni, Nicole Bouvy, F Borja de Lacy, Raphaëla Dresen, Konstantinos Ferentinos, Nader K Francis and 7 more

Open access · hybridAbstract readMeta-AnalysisPractice GuidelineSystematic Review
In one paragraph

Guideline in Surgical endoscopy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it, 17 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 14 institutions in 10 countries.

Marco MiloneDepartment of Clinical Medicine and Surgery, University "Federico II" of Naples, Naples, Italy. milone.marco.md@gmail.com.
Michel AdaminaDepartment of Surgery, Clinic of Visceral and Thoracic Surgery, Cantonal Hospital Winterthur, Winterthur, Switzerland.
Alberto ArezzoDepartment of Surgical Sciences, University of Torino, Torino, Italy.
Nona BejinariuDepartment of Pathology, Santomar Oncodiagnostic, Cluj-Napoca, Romania.
Luigi BoniDepartment of Surgery, Fondazione IRCCS - Ca' Granda - Ospedale Maggiore Policlinico University of Milan, Milan, Italy.
Nicole BouvyDepartment of Surgery, Maastricht University Medical Center, Maastricht, Netherlands.
F Borja de LacyDepartment of Gastrointestinal Surgery, Institute of Digestive and Metabolic Diseases, Hospital Clinic of Barcelona, Barcelona, Spain.
Raphaëla DresenUniversity Hospitals Leuven, Leuven, Belgium.
Konstantinos FerentinosDepartment of Radiation Oncology, German Oncology Center, Limassol, Cyprus.
Nader K FrancisDepartment of General Surgery, Yeovil District Hospital NHS Foundation Trust, Yeovil, UK.
Joe MahaffeyFight Colorectal Cancer, Springfield, MO, USA.
Marta PennaOxford University Hospitals, Oxford, UK.
George TheodoropoulosFirst Department of Propaedeutic Surgery of Athens, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Katerina Maria KontouliDepartment of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
Dimitris MavridisDepartment of Primary Education, School of Education, University of Ioannina, Ioannina, Greece.
Per Olav VandvikDepartment of Health Management and Health Economics, University of Oslo, Oslo, Norway.
Stavros A AntoniouSurgical Department, Mediterranean Hospital of Cyprus, Limassol, Cyprus.ORCID 0000-0002-4630-6748
Délégation Paris 5 · FREuropean University Cyprus · CYFederico II University Hospital · ITHospital Clínic de Barcelona · ESMaastricht University · NLNational and Kapodistrian University of Athens · GROxford University Hospitals NHS Trust · GBPhiladelphia Fight · USUniversity of Basel · CHUniversity of Ioannina · GRUniversity of Milan · ITUniversity of Oslo · NOUniversity of Turin · ITYeovil District Hospital NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence and practice recommendations on the use of transanal total mesorectal excision (TaTME) for rectal cancer are conflicting.

objectiveWe aimed to summarize best evidence and develop a rapid guideline using transparent, trustworthy, and standardized methodology.

methodsWe developed a rapid guideline in accordance with GRADE, G-I-N, and AGREE II standards. The steering group consisted of general surgeons, members of the EAES Research Committee/Guidelines Subcommittee with expertise and experience in guideline development, advanced medical statistics and evidence synthesis, biostatisticians, and a guideline methodologist. The guideline panel consisted of four general surgeons practicing colorectal surgery, a radiologist with expertise in rectal cancer, a radiation oncologist, a pathologist, and a patient representative. We conducted a systematic review and the results of evidence synthesis by means of meta-analyses were summarized in evidence tables. Recommendations were authored and published through an online authoring and publication platform (MAGICapp), with the guideline panel making use of an evidence-to-decision framework and a Delphi process to arrive at consensus.

resultsThis rapid guideline provides a weak recommendation for the use of TaTME over laparoscopic or robotic TME for low rectal cancer when expertise is available. Furthermore, it details evidence gaps to be addressed by future research and discusses policy considerations. The guideline, with recommendations, evidence summaries, and decision aids in user-friendly formats can also be accessed in MAGICapp: https://app.magicapp.org/#/guideline/4494 .

conclusionsThis rapid guideline provides evidence-informed trustworthy recommendations on the use of TaTME for rectal cancer.

Indexed as

LaparoscopyProctectomyRectal NeoplasmsTransanal Endoscopic SurgeryGRADE ApproachHumansPostoperative ComplicationsRectumClinical practice guidelineEAESGRADERectal cancerTaTMETransanal TME

Identifiers

PMID35212821
PMCPMC8921163
OpenAlexW4214734971

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.