Evidence map›Paper›PMID 35212788›Full record

ArticleAAPS PharmSciTech2022

Preparation and In Vitro and In Vivo Evaluation of a Testosterone Film Forming Gel for the Treatment of Hypoactive Sexual Desire Disorder in Women.

Jia Zeng, Tan-Fang Xie, Ting Huang, Fang Li, Zhi-Ping Wang, Ling-Lin Feng

Abstract read
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In one paragraph

Article in AAPS PharmSciTech, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jia Zeng *NHC Key Lab of Reproduction Regulation, Shanghai Engineer and Technology Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 200032, Shanghai, People's Republic of China.
Tan-Fang Xie *Department of Pharmaceutics, Key Laboratory of Common Technology of Traditional Chinese Medicine Preparation in Universities of Guangxi, Guangxi University of Chinese Medicine, 530020, Nanning, People's Republic of China.
Ting HuangNHC Key Lab of Reproduction Regulation, Shanghai Engineer and Technology Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 200032, Shanghai, People's Republic of China.
Fang LiNHC Key Lab of Reproduction Regulation, Shanghai Engineer and Technology Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 200032, Shanghai, People's Republic of China.
Zhi-Ping WangDepartment of Pharmaceutics, Key Laboratory of Common Technology of Traditional Chinese Medicine Preparation in Universities of Guangxi, Guangxi University of Chinese Medicine, 530020, Nanning, People's Republic of China. 318007460@qq.com.
Ling-Lin FengNHC Key Lab of Reproduction Regulation, Shanghai Engineer and Technology Research Center of Reproductive Health Drug and Devices, Shanghai Institute for Biomedical and Pharmaceutical Technologies, 200032, Shanghai, People's Republic of China. fenglinglinxin@163.com.
Guangxi University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hypoactive sexual desire disorder (HSDD) is one of the most common sexual complaints in women. Currently, there is an unmet need for a drug treatment for this disorder. The purpose of this study was to develop a testosterone (TS) film forming gel used for women to treat HSDD by measuring the tackiness, peel adhesion force, tensile strength, and elasticity of the formulation. Diethylene glycol monoethyl ether (Transcutol P), an efficient penetration enhancer, was added to the optimized formulation and the transdermal permeation characteristics in vitro were studied using Franz-diffusion cells. The quantitative determination of TS was performed by high-performance liquid chromatography (HPLC). After 24 h, Transcutol P at 3% had the largest cumulative amount of drug and enhancement ratio of TS of 75.14 μg/cm

Indexed as

Sexual Dysfunctions, PsychologicalSkin AbsorptionAdministration, CutaneousAnimalsFemaleHumansPolyvinyl AlcoholRabbitsSkinTestosteronePolyvinyl AlcoholTestosteronefilm forming gelin vitroin vivotestosteroneTranscutol P

Identifiers

PMID35212788
OpenAlexW4214693555

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.