Evidence map›Paper›PMID 35212735›Full record

Trial reportNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association2023

Effect of lanthanum carbonate on serum calciprotein particles in patients with stage 3-4 CKD-results from a placebo-controlled randomized trial.

Mark K Tiong, Edward R Smith, Elaine M Pascoe, Grahame J Elder, Nicole M Lioufas, Eugenia Pedagogos, Carmel M Hawley, Andrea Valks, Stephen G Holt, Tim D Hewitson and 1 more

Open access · bronzeAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Effect of the phosphate binder sucroferric oxyhydroxide in dialysis patients on endogenous calciprotein particles, inflammation, and vascular cells.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Trial
  3. The formation and function of calciprotein particles.Pflugers Archiv : European journal of physiology · 2025
    Review
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Mark K TiongDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.ORCID 0000-0001-9348-4638
Edward R SmithDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
Elaine M PascoeAustralasian Kidney Trials Network, The University of Queensland, Brisbane, Australia.
Grahame J ElderUniversity of Notre Dame, Sydney, Australia.
Nicole M LioufasDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
Eugenia PedagogosDepartment of Nephrology, Western Health, Sunshine, Australia.
Carmel M HawleyAustralasian Kidney Trials Network, The University of Queensland, Brisbane, Australia.
Andrea ValksAustralasian Kidney Trials Network, The University of Queensland, Brisbane, Australia.
Stephen G HoltDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
Tim D HewitsonDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
Nigel D ToussaintDepartment of Nephrology, The Royal Melbourne Hospital, Parkville, Australia.
The Royal Melbourne Hospital · AUThe University of Queensland · AUThe University of Sydney · AUTranslational Research Institute · AUWestern Health · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCalciprotein particles (CPP) are colloidal aggregates of calcium phosphate and the mineral-binding protein fetuin-A, and are potential mediators of cardiovascular disease in chronic kidney disease (CKD). Emerging evidence suggests non-calcium-containing phosphate binders may reduce serum CPP in patients with kidney failure who require dialysis; however, it is unclear whether similar interventions are effective in patients with earlier stages of CKD.

methodsThe IMpact of Phosphate Reduction On Vascular End-points in CKD (IMPROVE-CKD) was a multi-centre, placebo-controlled, randomized trial of lanthanum carbonate on cardiovascular markers in 278 participants with stage 3b/4 CKD. In this pre-specified exploratory analysis, primary (CPP-I) and secondary CPP (CPP-II) were measured in a sub-cohort of participants over 96 weeks. Treatment groups were compared using linear mixed-effects models and the relationship between serum CPP and pulse wave velocity (PWV) and abdominal aortic calcification (AAC) was examined.

resultsA total of 253 participants had CPP data for baseline and at least one follow-up timepoint and were included in this analysis. The mean age was 62.4 ± 12.6 years, 32.0% were female and the mean estimated glomerular filtration rate (eGFR) was 26.6 ± 8.3 mL/min/1.73 m2. Baseline median serum CPP-I was 14.9 × 104 particles/mL [interquartile range (IQR) 4.6-49.3] and median CPP-II was 3.3 × 103 particles/mL (IQR 1.4-5.4). There was no significant difference between treatment groups at 96 weeks in CPP-I [22.8% (95% confidence interval -39.2, 36.4), P = 0.65] or CPP-II [-18.3% (95% confidence interval -40.0, 11.2), P = 0.20] compared with a placebo. Serum CPP were not correlated with baseline PWV or AAC, or with the progression of either marker.

conclusionsLanthanum carbonate was not associated with a reduction of CPP at 96 weeks when compared with a placebo in a CKD cohort.

Indexed as

LanthanumRenal Insufficiency, ChronicAgedCalcium PhosphatesFemaleHumansMaleMiddle AgedPulse Wave AnalysisRenal Dialysiscalcium phosphateCalcium PhosphatesLanthanumlanthanum carbonatecalciprotein particlescardiovascular diseasechronic kidney diseasemineral metabolismphosphate binders

Identifiers

PMID35212735
PMCPMC9923701
OpenAlexW4213446056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.