Evidence map›Paper›PMID 35212626›Full record

ArticleeLife2022

KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.

Tingwei Guo, Xia Han, Jinzhi He, Jifan Feng, Junjun Jing, Eva Janečková, Jie Lei, Thach-Vu Ho, Jian Xu, Yang Chai

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
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  8. Upregulation ofCanadian respiratory journal · 2025
    Article
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  11. Inhibition ofInternational journal of molecular sciences · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Tingwei GuoCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID 0000-0003-4089-1867
Xia HanCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Jinzhi HeCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Jifan FengCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID 0000-0002-9944-2604
Junjun JingCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID 0000-0001-5745-5207
Eva JanečkováCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Jie LeiCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.
Thach-Vu HoCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID 0000-0001-6293-4739
Jian XuCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID 0000-0002-8162-889X
Yang ChaiCenter for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry, University of Southern California, Los Angeles, United States.ORCID 0000-0003-2477-7247
University of Southern California · US

Funding

USC FaceBase III Craniofacial Development and Dysmorpholoy Data Management and Integration HubU01DE028729 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG, KESSELMAN, CARL · 2019 to 2023
$13.9M
THE MOLECULAR REGULATORY MECHANISM OF TOOTH ROOT DEVELOPMENTR01DE022503 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Yang Chai · 2012 to 2026
$6.2M
TGF BETA SIGNALING AND MANDIBULAR MORPHOGENESISR01DE012711 · NIDCR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHAI, YANG · 1999 to 2023
$5.7M
NIDCR NIH HHS R01 DE012711NIDCR NIH HHS R01 DE022503NIDCR NIH HHS U01 DE028729
6 · The paper itself

Abstract

Epigenetic regulation plays extensive roles in diseases and development. Disruption of epigenetic regulation not only increases the risk of cancer, but can also cause various developmental defects. However, the question of how epigenetic changes lead to tissue-specific responses during neural crest fate determination and differentiation remains understudied. Using palatogenesis as a model, we reveal the functional significance of

Indexed as

Epigenesis, GeneticTumor Suppressor Protein p53AnimalsEmbryonic DevelopmentFemaleHistonesJumonji Domain-Containing Histone DemethylasesMicePregnancySignal TransductionTranscription Factor DP1HistonesJumonji Domain-Containing Histone DemethylasesKdm6b protein, mouseTfdp1 protein, mouseTranscription Factor DP1Tumor Suppressor Protein p53cleft palatecraniofacial developmentdevelopmental biologyepigenetic regulationmousetranscription regulation

Identifiers

PMID35212626
PMCPMC9007587
OpenAlexW4214508536

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.