ArticleeLife2022
Corticohippocampal circuit dysfunction in a mouse model of Dravet syndrome.
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Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32citing papers in PubMed
–field-weighted citation impact
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Who cites it
32 citing papers in PubMed.
- Article
- Persistent input- and cell-type-specific synaptic alterations in the somatosensory thalamus of Dravet syndrome mice.Journal of neurophysiology · 2026Article
- Chronic Stress Alters Dorsal Bed Nucleus of Stria Terminalis Synaptic Neurotransmission in a Dravet Syndrome Mouse Model.bioRxiv : the preprint server for biology · 2026Article
- Disrupted temperature-sleep coupling mechanism in a Dravet syndrome mouse model.Nature communications · 2026Article
- Piriform seizures mediated by the piriform-entorhino-dentate circuit induce brain-wide functional reorganization in mice.PLoS biology · 2026Article
- Medial septum parvalbumin-expressing inhibitory neurons are impaired in a mouse model of Dravet syndrome.Epilepsia · 2025Article
- Transgenic mouse models of sodium and potassium channelopathies in epilepsy: insights into disease mechanisms and therapeutics.Bioscience reports · 2025Review
- Depolarization block induction via slow NaScientific reports · 2025Article
- Early and widespread cerebellar engagement during hippocampal seizures and interictal discharges.Neurobiology of disease · 2025Article
- Distinct changes to hippocampal and medial entorhinal circuits emerge across the progression of cognitive deficits in epilepsy.Cell reports · 2025Article
- Allele-Specific Editing of a Dominant SCN8A Epilepsy Variant Protects against Seizures and Lethality in a Murine Model.Annals of neurology · 2024Article
- Dentate gyrus granule cells are a locus of pathology in Scn8a developmental encephalopathy.Neurobiology of disease · 2024Article
- New complex physiological findings evolve hypothesized mechanisms of Dravet syndrome.Neural regeneration research · 2024Article
- The critical dynamics of hippocampal seizures.Nature communications · 2024Article
- Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer's pathology.Nature communications · 2024Article
- Seizure event detection using intravital two-photon calcium imaging data.Neurophotonics · 2024Article
- Unraveling the Neural Circuits: Techniques, Opportunities and Challenges in Epilepsy Research.Cellular and molecular neurobiology · 2024Review
- Complex Synaptic and Intrinsic Interactions Disrupt Input/Output Functions in the Hippocampus ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Seizure Event Detection Using Intravital Two-Photon Calcium Imaging Data.bioRxiv : the preprint server for biology · 2023Article
- Morphometry and network-based atrophy patterns in SCN1A-related Dravet syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
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Authors and funding
10 authors.
Joanna MattisDepartment of Neurology, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, United States.ORCID 0000-0003-0341-1270
Ala SomarowthuDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Kevin M GoffNeuroscience Graduate Group, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.ORCID 0000-0001-5862-0219
Evan JiangDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Jina YomCollege of Arts and Sciences, The University of Pennsylvania, Philadelphia, United States.
Nathaniel SotuyoNeuroscience Graduate Group, The University of Pennsylvania Perelman School of Medicine, Philadelphia, United States.
Laura M McgarryDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Huijie FengDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.
Keisuke KanekoDivision of Neurology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, United States.ORCID 0000-0002-5071-0057
Ethan M GoldbergDepartment of Neurology, The Perelman School of Medicine at The University of Pennsylvania, Philadelphia, United States.ORCID 0000-0002-7404-735X
Funding
Phenotypic Diversity in COVID-19UL1TR001878 · NCATS · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2016 to 2025
$102.4MInterneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndromeR01NS110869 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI ETHAN M GOLDBERG · 2019 to 2026
$3.5MResearch Training Program in Disease Oriented Neuroscience (R25)R25NS065745 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI DETRE, JOHN A · 2009 to 2023
$3.0MCortico-hippocampal circuit dysfunction in an Scn1a mouse model of epilepsyK08NS121464 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI MATTIS, JOANNA H · 2021 to 2025
$969kDynamic two-photon calcium imaging and optogenetic manipulation of epileptic brain circuits in an experimental model of temporal lobe epilepsyK08NS097633 · NINDS · CHILDREN'S HOSP OF PHILADELPHIA · PI GOLDBERG, ETHAN M · 2016 to 2020
$921kNCATS NIH HHS UL1 TR001878NINDS NIH HHS K08 NS097633NINDS NIH HHS K08 NS121464NINDS NIH HHS R01 NS110869NINDS NIH HHS R25 NS065745
Abstract
Dravet syndrome (DS) is a neurodevelopmental disorder due to pathogenic variants in
Indexed as
Autism Spectrum DisorderEpilepsies, MyoclonicAnimalsDisease Models, AnimalEpileptic SyndromesInterneuronsMiceNAV1.1 Voltage-Gated Sodium ChannelSeizuresSpasms, InfantileNAV1.1 Voltage-Gated Sodium ChannelScn1a protein, mousedentate gyrusDravet syndromegabaergic interneuronsgeneticsgenomicsmouseNav1.1neuroscienceSCN1A
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.