Evidence map›Paper›PMID 35212606›Full record

ArticleBioengineered2022

Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis.

Shan Cao, Ying Huang, Zhenzhao Dai, Yang Liao, Jinfeng Zhang, Lingli Wang, Zhiyan Hao, Fei Wang, Dan Wang, Lixiao Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineered, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  16. CircRNA-mediated regulation of cardiovascular disease.Frontiers in cardiovascular medicine · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Shan CaoDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Ying HuangDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Zhenzhao DaiDepartment of Pediatrics, Affiliated Hospital of Jinggangshan University, Jiangxi, China.
Yang LiaoDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Jinfeng ZhangDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Lingli WangDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Zhiyan HaoDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Fei WangDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Dan WangDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Lixiao LiuDepartment of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, Pudong, 201399 China.
Fudan University · CNPudong Medical Center · CNJinggangshan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Microvascular dysfunction causes mortality in the presence of sepsis and multi-organ failure. Previous studies have demonstrated that exogenous administration of exosomes from adipose-derived mesenchymal stem cells (ADSCs) protects against sepsis, improves organ function, decreases vascular leakage and increases survival. However, the underlying regulatory mechanism was largely unknown. Therefore, in this study, a mouse sepsis model based on cecal ligation and puncture (CLP) was constructed. Exosomes from various ADSCs were intravenously administered at 4 h post CLP. Treatment with ADSC exosomes (Exo), particularly those with hypoxic pretreatment (HExo), enhanced survival, suppressed renal vascular leakage and decreased kidney dysfunction in septic mice. HExo ameliorated sepsis-induced increases in chemokine and cytokine plasma levels. Furthermore, the HExo circRNA content, determined through next-generation sequencing, revealed abundant mmu_circ_0001295. Further studies demonstrated that downregulation of exosomal mmu_circ_0001295 suppressed the exosomes' protective effects against sepsis. HExo prevented microvascular dysfunction, thus potentially improving sepsis outcomes via mmu_circ_0001295 delivery. In summary, the data indicated that HExo elongate sepsis-induced renal injury through delivering mmu_circ_0001295.

Indexed as

ExosomesKidney DiseasesMesenchymal Stem CellsAnimalsCell HypoxiaDisease Models, AnimalKidneyMiceMice, Inbred C57BLRNA, CircularSepsisRNA, Circularadipose-derived mesenchymal stem cells (ADSCS)cecal ligation and puncture (CLP)exosomemmu_circ_0001295sepsis

Identifiers

PMID35212606
PMCPMC8974218
OpenAlexW4214633546

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.