ArticleThe Journal of urology2022
Impact of Sleep Disturbance, Physical Function, Depression and Anxiety on Male Lower Urinary Tract Symptoms: Results from the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN).
Article in The Journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06062875 (Effects of TNF Blockade on Human BPH/LUTS), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of TNF Blockade on Human BPH/LUTS
Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Frailty burden and symptomatic BPH/LUTS in aging men: evidence from two nationally representative population-based studies.World journal of urology · 2026Article
- Gaps in patient-reported outcome measures integration into the management of lower urinary tract symptoms attributed to benign prostatic hyperplasia (LUTS/BPH): qualitative insights for implementation strategies.Journal of patient-reported outcomes · 2026Article
- Symptoms and subtypes of patients with lower urinary tract dysfunction - insights from the Symptoms of Lower Urinary Tract Dysfunction Research Network.Nature reviews. Urology · 2026Review
- Comment on: "Effect of melatonin on postoperative cognitive function in elderly patients submitted to transurethral resection of the prostate under spinal anesthesia".Clinics (Sao Paulo, Brazil) · 2026Article
- Impact of preoperative antidepressant use on surgical and functional outcomes of robot assisted radical prostatectomy.Scientific reports · 2025Article
- Multivariable regression analysis of perioperative parameters for a novel pulsed solid-state Thulium: YAG laser with high peak power versus Holmium: YAG laser in prostate enucleation.World journal of urology · 2025Article
- Exploring the Association Between Urinary Incontinence and Depression Based on a Series of Large-Scale National Health Studies in Türkiye.Journal of clinical medicine · 2025Article
- Social function scores and influencing factors in patients with residual depressive symptoms.World journal of psychiatry · 2025Article
- Self-care conditioning factors in women and men with urinary incontinence and Human T-Lymphotropic Virus Type 1.Revista da Escola de Enfermagem da U S P · 2025Article
- Relationship of psychotropic medication use with physical function among postmenopausal women.GeroScience · 2024Article
- Enhanced clinical decisions for management of benign prostatic hyperplasia using patient-reported outcomes: protocol for a prospective observational study.BMC urology · 2024Observational
- Enhanced Clinical Decisions for Management of Benign Prostatic Hyperplasia using Patient-Reported Outcomes: Protocol for a Prospective Observational Study.Research square · 2024Article
- Correlation between metabolic syndrome and periurethral prostatic fibrosis: results of a prospective study.BMC urology · 2024Article
Corrections and comments
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Authors and funding
17 authors at 11 institutions in 1 country.
Funding
Abstract
purposeThe impact of nonurological factors on male lower urinary tract symptoms (LUTS) remains unclear. We investigated cross-sectional and longitudinal associations among anxiety, depression, physical function, sleep quality and urinary symptom subdomains. MATERIALS AND
methodsData from 518 men in the LURN (Symptoms of Lower Urinary Tract Dysfunction Research Network) study were analyzed to identify associations between Patient-Reported Outcomes Measurement Information System® (PROMIS®) depression, anxiety, sleep disturbance and physical function measures and LUTS subdomains, as derived from the American Urological Association Symptom Index and LUTS Tool. Multivariable linear regression was used to assess the relationships between PROMIS measures and LUTS subdomains at baseline and at 3- and 12-month followup.
resultsBaseline depression and anxiety were associated with urinary incontinence (p <0.001), voiding symptoms (p <0.001) and quality of life (p=0.002), whereas baseline sleep disturbance was associated with voiding and storage symptoms and quality of life (p <0.001 for all). Urinary symptom severity improved in all subdomains at 3 and 12 months. Similar associations between PROMIS measures and LUTS subdomains were observed at all time points, but baseline depression, anxiety, sleep disturbance and physical function measures were not associated with longitudinal trajectories of LUTS.
conclusionsUrinary symptom subdomains are independently associated with modifiable clinical variables including sleep quality and depression at all time points, but these variables do not predict the degree of improvement in LUTS following urological evaluation and treatment over the medium term. Bidirectional assessment and randomized experiments may improve our understanding of these relationships.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.