Evidence map›Paper›PMID 35212415›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2022

The use of connective tissue growth factor mimics for flexor tendon repair.

Hua Shen, Solaiman Tarafder, Gayoung Park, Jichuan Qiu, Younan Xia, Chang H Lee, Richard H Gelberman, Stavros Thomopoulos

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. The effects of NF-κB suppression on the early healing response following intrasynovial tendon repair in a canine model.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Hua ShenDepartment of Orthopedic Surgery, Washington University, St. Louis, Missouri, USA.ORCID 0000-0001-9060-8172
Solaiman TarafderDepartment of Oral and Maxillofacial Surgery, Columbia University, New York, New York, USA.
Gayoung ParkDepartment of Oral and Maxillofacial Surgery, Columbia University, New York, New York, USA.
Jichuan QiuDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Younan XiaDepartment of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA.
Chang H LeeDepartment of Oral and Maxillofacial Surgery, Columbia University, New York, New York, USA.
Richard H GelbermanDepartment of Orthopedic Surgery, Washington University, St. Louis, Missouri, USA.ORCID 0000-0003-2457-6867
Stavros ThomopoulosDepartment of Orthopaedic Surgery, Columbia University, New York, New York, USA.ORCID 0000-0003-1531-4849
Columbia University · USGeorgia Institute of Technology · USWashington University in St. Louis · US

Funding

Resource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8M
Enhanced Tendon Healing Through Growth Factor and Cell TherapiesR01AR062947 · NIAMS · WASHINGTON UNIVERSITY · PI GELBERMAN, RICHARD H, THOMOPOULOS, STAVROS · 2012 to 2022
$5.5M
NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R01 AR062947
6 · The paper itself

Abstract

Intrasynovial flexor tendon lacerations of the hand are clinically problematic, typically requiring operative repair and extensive rehabilitation. The small-molecule connective tissue growth factor (CTGF) mimics, oxotremorine M (Oxo-M) and 4-PPBP maleate (4-PPBP), have been shown to improve tendon healing in small animal models by stimulating the expansion and differentiation of perivascular CD146+ cells. To enhance intrasynovial flexor tendon healing, small-molecule CTGF mimics were delivered to repaired canine flexor tendons via porous sutures. In vitro studies demonstrated that Oxo-M and 4-PPBP retained their bioactivity and could be released from porous sutures in a sustained manner. However, in vivo delivery of the CTGF mimics did not improve intrasynovial tendon healing. Histologic analyses and expression of tenogenic, extracellular matrix, inflammation, and remodeling genes showed similar outcomes in treated and untreated repairs across two time points. Although in vitro experiments revealed that CTGF mimics stimulated robust responses in extrasynovial tendon cells, there was no response in intrasynovial tendon cells, explaining the lack of in vivo effects. The results of the current study indicate that therapeutic strategies for tendon repair must carefully consider the environment and cellular makeup of the particular tendon for improving the healing response.

Indexed as

Connective Tissue Growth FactorTendonsAnimalsCell DifferentiationDogsHaloperidolSutures4-phenyl-1-(4-phenylbutyl)piperidineConnective Tissue Growth FactorHaloperidol4-PPBPCTGFintrasynovial flexor tendonOxo-M

Identifiers

PMID35212415
PMCPMC9402796
OpenAlexW4214608816

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.