Evidence map›Paper›PMID 35212407›Full record

ArticleLasers in surgery and medicine2022

Monitoring silver diamine fluoride application with optical coherence tomography and thermal imaging: An in vitro proof of concept study.

Marwa Abdelaziz, Vincent Yang, Nai-Yuan Nicholas Chang, Cynthia Darling, William Fried, Jong Seto, Daniel Fried

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Lasers in surgery and medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Silver diamine fluoride differentially affects dentin and hypomineralized enamel permeabilities.Dental materials : official publication of the Academy of Dental Materials · 2025
    Article
  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Marwa AbdelazizDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.ORCID 0000-0002-9715-879X
Vincent YangDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.
Nai-Yuan Nicholas ChangDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.
Cynthia DarlingDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.
William FriedDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.
Jong SetoDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.
Daniel FriedDepartment of Preventive and Restorative Dental Science, UCSF, San Francisco, California, USA.ORCID 0000-0002-5327-2558
Preventive Medicine Research Institute · USUniversity of Geneva · CH

Funding

Optical Methods for Lesion Activity AssessmentR01DE027335 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FRIED, DANIEL · 2018 to 2022
$1.9M
Infrared Methods for Lesion Activity AssessmentF30DE027264 · NIDCR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHANG, NAI-YUAN NICHOLAS · 2017 to 2021
$244k
NIDCR NIH HHS F30 DE027264NIDCR NIH HHS R01 DE027335
6 · The paper itself

Abstract

objectivesThe purpose of this study was to show that optical coherence tomography (OCT) and thermal imaging can be used to monitor changes in the structure and activity of caries lesions over time after treatment with silver diamine fluoride (SDF).

methodsArtificial caries lesions were formed on enamel and dentin bovine blocks. Each block was partitioned into five windows with the central three windows exposed to a demineralization solution to create lesions: one sound window served as a sound control (SC), one sound window was exposed to SDF to serve as a test control (SCT), one lesion window served as a lesion control (LC), one lesion window received one application of SDF (L1), while the other lesion window received two applications of SDF (L2). Each window was scanned using OCT before SDF application, and every week subsequently, for 12 weeks after initial SDF treatment. Changes in the mean intensity and the width of the peak of increased reflectivity due to the lesion and SDF along with the intensity at a depth of 180 µm from the surface representing optical penetration through the lesion were monitored. Changes in the heat lost, ΔQ (temperature integrated over time) of each window during drying with air were also monitored using a thermal imaging camera. Transverse microradiography (TMR), and high-resolution microscopy were also used for the analysis of selected samples.

resultsThe reflectivity and optical penetration of sound and lesion areas of enamel and dentin manifested significant changes in OCT images after SDF application. Thermal imaging showed significant differences in ΔQ indicative of permeability changes in the sound and lesion areas of enamel and dentin after SDF application.

Indexed as

Dental CariesTomography, Optical CoherenceAnimalsCattleDentinFluorides, TopicalProof of Concept StudyQuaternary Ammonium CompoundsSilver CompoundsFluorides, TopicalQuaternary Ammonium CompoundsSilver Compoundssilver diamine fluoridecariesmonitoring lesion activityOCToptical coherence tomographySDFsilver diamine fluoridethermal imaging

Identifiers

PMID35212407
PMCPMC9189075
OpenAlexW4214735450

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.