ArticleCerebral cortex (New York, N.Y. : 1991)2022
Sex-related brain connectivity correlates of compensation in adults with autism: insights into female protection.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Autistic Traits and Camouflaging: A Meta-Analysis.Autism : the international journal of research and practice · 2026Pooled it
- A meta-analytic review of quantification methods for camouflaging behaviors in autistic and neurotypical individuals.Scientific reports · 2025Pooled it
- Immune and Autoimmune Mechanisms in Autism Spectrum Disorder: Linking Molecular Pathways to Neuropsychological Trajectories Across the Lifespan.International journal of molecular sciences · 2026Review
- Article
- Large-scale neural network compensation associated with camouflaging in trait autism and its potential mental health costs.Molecular autism · 2026Article
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
- Sex Differences in Functional Gradients and Dynamic Functional Connectivity in Preschool-Aged Children With ASD.CNS neuroscience & therapeutics · 2025Article
- Sex differences in brain-behavior relationships in the first 2 years of life.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Regulation of craving and underlying resting-state neural circuitry predict hazard of smoking lapse.Translational psychiatry · 2025Article
- Sex differences in brain functional specialization and interhemispheric cooperation among children with autism spectrum disorders.Scientific reports · 2024Article
- Sensorimotor regulation of facial expression - An untouched frontier.Neuroscience and biobehavioral reviews · 2024Review
- Differently different?: A commentary on the emerging social cognitive neuroscience of female autism.Biology of sex differences · 2024Review
- Brain-wide connectome inferences using functional connectivity MultiVariate Pattern Analyses (fc-MVPA).PLoS computational biology · 2022Article
- Low glutamate diet improves working memory and contributes to altering BOLD response and functional connectivity within working memory networks in Gulf War Illness.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The male preponderance in autism spectrum disorder (ASD) led to the hypothesis that aspects of female biology are protective against ASD. Females with ASD (ASD-F) report more compensatory behaviors (i.e. "camouflaging") to overcome ASD-related social differences, which may be a mechanism of protection. No studies have examined sex-related brain pathways supporting camouflaging in ASD-F, despite its potential to inform mechanisms underlying the ASD sex bias. We used functional connectivity (FC) to investigate "sex-atypical" and "sex-typical" FC patterns linked to camouflaging in adults with ASD and examined multimodal coherence of findings via structural connectometry. Exploratory associations with cognitive/emotional functioning examined the adaptive nature of FC patterns. We found (i) "sex-atypical" FC patterns linked to camouflaging in the hypothalamus and precuneus and (ii) "sex-typical" patterns in the right anterior cingulate and anterior parahippocampus. Higher hypothalamic FC with a limbic reward cluster also correlated with better cognitive control/emotion recognition. Structural connectometry validated FC results with consistent brain pathways/effect patterns implicated in ASD-F. In summary, "male-typical" and "female-typical" brain connectivity patterns support camouflaging in ASD-F in circuits implicated in reward, emotion, and memory retrieval. "Sex-atypical" results are consistent with fetal steroidogenic/neuroinflammatory hypotheses. However, female genetics/biology may contribute to "female-typical" patterns implicated in camouflaging.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.