ArticleJournal of cachexia, sarcopenia and muscle2022
Obesity is associated with improved postoperative overall survival, independent of skeletal muscle mass in lung adenocarcinoma.
Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 35 citations in OpenAlex.
- Automated three-dimensional radiomic body composition analysis enhances survival prediction in resectable non‑small cell lung cancer.European radiology experimental · 2026Article
- Impact of Muscle Mass Loss on Survival During Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: A Multi-center Retrospective Study in China (TIMES Study).Annals of surgical oncology · 2026Article
- Body composition radiomics integrated with machine learning to predict prognosis in advanced NSCLC treated with first-line immunochemotherapy and concurrent radiotherapy.BMC pulmonary medicine · 2026Article
- Novel Long-Acting Ghrelin Analogue PEP-064 Restores Energy Balance in C26 and Lewis Lung Carcinoma-Induced cachexia in Mice.Journal of cachexia, sarcopenia and muscle · 2026Article
- The Interplay of Preoperative Sarcopenia, Systemic Inflammation, and Neoadjuvant Therapy in Resectable NSCLC-Identifying the Gap: A Narrative Review of Surgical and Oncological Outcomes.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- Comparison of the Changes in Visceral Adipose Tissue After Lobectomy and Segmentectomy for Patients With Early-Stage Lung Cancer.Journal of cachexia, sarcopenia and muscle · 2025Article
- Multiparameter body composition analysis on chest CT predicts clinical outcomes in resectable non-small cell lung cancer.Insights into imaging · 2025Article
- How different body compositions affect the prognosis of HCC undergoing immunotherapy: the paradoxical phenomenon of BMI.La Radiologia medica · 2025Article
- The association between body composition and overall survival in patients with advanced non-small cell lung cancer.Scientific reports · 2025Article
- Frequency of weight and body composition increases in advanced non-small cell lung cancer patients during first line therapy.Journal of cachexia, sarcopenia and muscle · 2024Article
- Lung cancer and obesity: A contentious relationship (Review).Oncology reports · 2024Review
- Regimen on Dnaja3 haploinsufficiency mediated sarcopenic obesity with imbalanced mitochondrial homeostasis and lipid metabolism.Journal of cachexia, sarcopenia and muscle · 2024Article
- Influence of abdominal fat distribution and inflammatory status on post-operative prognosis in non-small cell lung cancer patients: a retrospective cohort study.Journal of cancer research and clinical oncology · 2024Article
- Obesity worsens mitochondrial quality control and does not protect against skeletal muscle wasting in murine cancer cachexia.Journal of cachexia, sarcopenia and muscle · 2024Article
- The MAPS-CRAFITY score: a novel efficacy predictive tool for unresectable hepatocellular carcinoma treated with targeted therapy plus immunotherapy.Hepatology international · 2023Article
- Prognostic significance of body mass index in small-cell lung cancer: Exploring the relationship with skeletal muscle status.Journal of cachexia, sarcopenia and muscle · 2023Article
- Obesity paradox in patients with non-small cell lung cancer undergoing immune checkpoint inhibitor therapy.Journal of cachexia, sarcopenia and muscle · 2023Article
- Increased adipose tissue is associated with improved overall survival, independent of skeletal muscle mass in non-small cell lung cancer.Journal of cachexia, sarcopenia and muscle · 2023Article
- Ectopic and visceral fat deposition in aging, obesity, and idiopathic pulmonary fibrosis: an interconnected role.Lipids in health and disease · 2023Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough the obesity paradox is a topic of immense interest for oncologists and epidemiologists, the mechanism underlying this unexpected benefit of obesity is poorly understood. We explored the prognostic value of obesity and its association with skeletal muscle mass.
methodsThis retrospective study evaluated the data of patients who underwent surgical excision for lung adenocarcinoma between January 2011 and December 2015. Body mass index was categorized according to the criteria of the Asia-Pacific classification. Cross-sectional areas of the skeletal muscle, subcutaneous fat, and visceral fat were measured. Skeletal muscle mass status was defined based on the cut-offs of skeletal muscle index (cm
resultsA total of 636 patients with a median age of 61 years (interquartile range, 54.0-68.5 years; 321 men and 315 women) were included. Obese patients (body mass index ≥ 25 kg/m
conclusionsObesity was associated with favourable overall survival, independent of skeletal muscle mass, after surgical excision of lung adenocarcinoma.
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