Evidence map›Paper›PMID 35212175›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

Changes in predicted lean body mass, appendicular skeletal muscle mass, and body fat mass and cardiovascular disease.

Seong Rae Kim, Gyeongsil Lee, Seulggie Choi, Yun Hwan Oh, Joung Sik Son, Minseon Park, Sang Min Park

Open access · goldAbstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 55 citations in OpenAlex.

  1. Trial
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  4. Lean body mass index and hypertension risk in men: a nationwide epidemiological cohort study.Hypertension research : official journal of the Japanese Society of Hypertension · 2026
    Article
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  6. Exploring obesity phenotypes: a longitudinal perspective.Reviews in endocrine & metabolic disorders · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Seong Rae KimDepartment of Dermatology, Seoul National University College of Medicine, Seoul, South Korea.
Gyeongsil LeeDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Seulggie ChoiDepartment of Biomedical Sciences, Seoul National University Graduate School, Seoul, South Korea.
Yun Hwan OhDepartment of Family Medicine, Jeju National University School of Medicine, Jeju, South Korea.
Joung Sik SonDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Minseon ParkDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Sang Min ParkDepartment of Family Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, South Korea.
Seoul National University · KRSeoul National University Hospital · KRJeju National University · KR

Funding

Ministry of Health and Welfare, Republic of Korea
6 · The paper itself

Abstract

backgroundLittle is known about the association of changes in two body components, muscle and fat mass, with the risk of cardiovascular disease (CVD) among young adults. We investigated the association of changes in predicted lean body mass index (LBMI), appendicular skeletal muscle mass index (ASMI), and body fat mass index (BFMI) with the development of CVD among young adults.

methodsThis nationwide, population-based cohort study included 3 727 738 young adults [2 406 046 (64.5%) men and 1 321 692 (35.5%) women] aged 20-39 years without a previous history of CVD who underwent two health screening examinations during 2009-2010 and 2011-2012. Using validated and robust prediction equations, we calculated the changes in predicted LBMI, ASMI, and BFMI from the first to the second examinations.

resultsThe mean (SD) age was 32.2 (4.9) years, and 2 406 046 (64.5%) of the participants were men. A total of 23 344 CVD events were detected during 22 257 632 person-years of follow-up. Each 1 kg/m

conclusionsAmong young adults, increased predicted muscle mass or decreased predicted fat mass were associated with a reduced risk of development of CVD. Decreased predicted muscle mass or increased predicted fat mass were associated with an elevated risk of development of CVD.

Indexed as

Cardiovascular DiseasesAdipose TissueAdultBody CompositionCohort StudiesFemaleHumansMaleMuscle, SkeletalYoung AdultAppendicular skeletal muscle massBody fat massCardiovascular diseaseLean body massYoung adults

Identifiers

PMID35212175
PMCPMC8978024
OpenAlexW4214518068

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.