ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2022
Microbiota of the first-pass meconium and subsequent atopic and allergic disorders in children.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 3 of them syntheses that pooled it.
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Who cites it
9 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Microbiota Signatures in Early Life and Their Association With Food Allergy: A Systematic Review.Allergy · 2026Pooled it
- Global Microbiome: Core and Unique Signatures Across Diverse Populations.International journal of molecular sciences · 2026Pooled it
- Investigating prenatal and perinatal factors on meconium microbiota: a systematic review and cohort study.Pediatric research · 2024Pooled it
- Analysis of intestinal microorganisms and metabolite in childhood allergic asthma: role in assessing the severity of condition in children.Frontiers in pediatrics · 2025Article
- Temporal Investigation of the Maternal Origins of Fetal Gut Microbiota.Microorganisms · 2024Article
- The First 1000 Days of Life: How Changes in the Microbiota Can Influence Food Allergy Onset in Children.Nutrients · 2023Review
- Early Gut Microbiota Profile in Healthy Neonates: Microbiome Analysis of the First-Pass Meconium Using Next-Generation Sequencing Technology.Children (Basel, Switzerland) · 2023Article
- Article
- Microbiota of the first-pass meconium and subsequent atopic and allergic disorders in children.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2022Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSome cohort studies have suggested that gut microbiota composition is associated with allergic diseases in children. The microbiota of the first-pass meconium, which forms before birth, represents the first gut microbiota that is easily available for research and little is known about any relationship with allergic disease development.
objectiveWe investigated whether the bacterial composition of the first-pass meconium is associated with the development of allergic diseases before 4 years of age.
methodsProspective birth cohort study. Bacterial composition of first-pass meconium was analysed using bacterial 16S rRNA gene amplicon sequencing. Atopic and allergic diseases were evaluated via online survey or telephone to age 4 years, based on the International Study of Asthma and Allergies in Childhood questionnaire.
resultsDuring a 6-week period in 2014, 312 children were born at the Central Finland Central Hospital. Meconium was collected from 212 at a mean of 8-hour age. Outcome data at 4 years were available for 177 (83%) children, and 159 of these had sufficient amplification of bacterial DNA in meconium. Meconium microbiota composition, including diversity indices and relative abundances of the main phyla and genera, was not associated with subsequent atopic eczema, wheezing or cow's milk allergy. Principal components analysis did not identify any clustering of the meconium microbiomes of children with respect to wheezing or cow's milk allergy.
conclusionsWe found no evidence that gut microbiota composition of first-pass meconium is associated with atopic manifestations to age 4 years. However, larger studies are needed to fully exclude a relationship.
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