Observational studyPediatric nephrology (Berlin, Germany)2022
Creatinine-based GFR-estimating equations in children with overweight and obesity.
Observational study in Pediatric nephrology (Berlin, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02091544 (Kijk op Overgewicht Bij Kinderen), which is not on this map. Cited by 13 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Kijk op Overgewicht Bij Kinderen: Study Regarding Etiological Factors, Risk Factors and Early Stages of Chronic Disease in Different Degrees of Childhood Overweight
Who cites it
13 citing papers in PubMed, 17 citations in OpenAlex.
- Association of Serum Creatinine, Urea, and Glomerular Filtration Rate with the Progression of Diabetic Associated Kidney Complications: A Retrospective Case-Control Study.Current issues in molecular biology · 2026Article
- Pharmacokinetics and Childhood Obesity: Pathophysiological Basis and Challenges in Choosing the Ideal Body Size Descriptor.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Associations of trimethylamine N-oxide (TMAO) and its precursors with childhood obesity: a case-control study.BMC endocrine disorders · 2025Article
- The evaluation of kidney function estimation during lifestyle intervention in children with overweight and obesity.Pediatric nephrology (Berlin, Germany) · 2024Observational
- Estimated glomerular filtration rate: applicability of creatinine-based equations in African children.Pediatric nephrology (Berlin, Germany) · 2024Article
- Prevalence and associated factors of impaired kidney functions among children and adolescents in India: insights from the Comprehensive National Nutrition Survey (CNNS) 2016-18.BMC pediatrics · 2024Article
- Extending the cystatin C based EKFC-equation to children - validation results from Europe.Pediatric nephrology (Berlin, Germany) · 2024Article
- Childhood Obesity: Insight into Kidney Involvement.International journal of molecular sciences · 2023Review
- Estimated pediatric glomerular filtration rate presentation improves the detection rate of kidney impairment in children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Glomerular hyperfiltration: part 2-clinical significance in children.Pediatric nephrology (Berlin, Germany) · 2023Review
- Relation between obesity-related comorbidities and kidney function estimation in children.Pediatric nephrology (Berlin, Germany) · 2023Article
- Lipid metabolism and renal function markers in obese adolescents.Pediatric endocrinology, diabetes, and metabolism · 2023Article
- [Current clinical application of glomerular filtration rate assessment methods in pediatric populations].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsReview
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith the increasing prevalence of childhood obesity and related development of chronic kidney disease (CKD), there is a critical need to understand how best to assess kidney function in children with obesity. Since serum creatinine (SCr) is recommended as marker of first choice for GFR estimation, we evaluated and compared creatinine-based GFR equations in children with overweight and obesity.
methodsSix hundred children with overweight and obesity (53.5% female; mean age 12.20 ± 3.28 years; mean BMI z-score 3.31 ± 0.75) were included from the Centre for Overweight Adolescent and Children's Healthcare (COACH).
resultsSerum creatinine (SCr), normalized using Q-age polynomials obtained from reference values, results in median and mean SCr/Q value close to "1" for all age groups, and 96.5% of the children have a SCr/Q within the reference band [0.67-1.33], corresponding to the 2.5th and 97.5th percentile. eGFR CKiD (bedside Schwartz equation) and Schwartz-Lyon decreased with age, whereas eGFR EKFC and modified CKD-EPI40 showed no age-dependency, but the distribution of eGFR values was not symmetrical. eGFR CKiD under 25 (CKiDU25) demonstrated no age-dependency but major sex differences were observed. eGFR FAS age, FAS height, and adjusted-creatinine revised Lund-Malmö (LMR18) showed a relatively symmetrical distribution and no age-dependency.
conclusionsSerum creatinine (SCr) values of children with overweight and obesity are mostly within the reference range for children. Normalization of SCr using reference Q-age polynomials works very well in this cohort. After evaluation of the different equations, we suggest that FAS age, FAS height, and LMR18 are the preferred creatinine-based GFR-estimating equations in children with overweight and obesity. CLINICAL
trial registrationCLINICALTRIAL: gov; Registration Number: NCT02091544. A higher resolution version of the Graphical abstract is available as Supplementary information.
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