Evidence map›Paper›PMID 35211765›Full record

ArticleMolecular medicine reports2022

Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs.

Rachel Kerslake, Harpal S Randeva, Danny Jonigk, Christopher Werlein, Jan L Robertus, Periklis Katopodis, Petra Jasker, Demetrios A Spandidos, Ioannis Kyrou, Emmanouil Karteris

Open access · hybridAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Rachel KerslakeDivision of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH.
Harpal S RandevaWarwickshire Institute for The Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, Coventry CV2 2DX, UK.
Danny JonigkInstitute for Pathology, Hannover Medical School, D‑30625 Hannover, Germany.
Christopher WerleinInstitute for Pathology, Hannover Medical School, D‑30625 Hannover, Germany.
Jan L RobertusNational Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
Periklis KatopodisDivision of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Petra JaskerPathologie Grünstrasse, D‑40212 Düsseldorf, Germany.
Demetrios A SpandidosLaboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Greece.
Ioannis Kyrou *Warwickshire Institute for The Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, Coventry CV2 2DX, UK.
Emmanouil Karteris *Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Brunel University of London · GBMedizinische Hochschule Hannover · DEUniversity Hospitals Coventry and Warwickshire NHS Trust · GBImperial College London · GBUniversity of Crete · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to the angiotensin‑converting enzyme 2 (ACE2), a number of host cell entry mediators have been identified for severe acute respiratory syndrome coronavirus‑2 (SARS‑CoV‑2), including transmembrane protease serine 4 (TMPRSS4). The authors have recently demonstrated the upregulation of TMPRSS4 in 11 different cancers, as well as its specific expression within the central nervous system using

Indexed as

AgedAngiotensin-Converting Enzyme 2COVID-19Gastrointestinal TractHumansImmunohistochemistryLungLung NeoplasmsMaleMembrane ProteinsSARS-CoV-2Serine EndopeptidasesVirus InternalizationACE2 protein, humanAngiotensin-Converting Enzyme 2Membrane ProteinsSerine EndopeptidasesTMPRSS4 protein, humancoronavirus disease 2019gastrointestinal tractlungsevere acute respiratory syndrome coronavirus‑2transmembrane protease serine 4tropism

Identifiers

PMID35211765
PMCPMC8908323
OpenAlexW4213420239

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.