Evidence map›Paper›PMID 35211693›Full record

ArticleFrontiers in global women's health2021

Postpartum State, but Not Maternal Caregiving or Level of Anxiety, Increases Medial Prefrontal Cortex GAD

Christina M Ragan, Eman I Ahmed, Erika M Vitale, Katrina Linning-Duffy, Stephanie M Miller-Smith, Jamie Maguire, Joseph S Lonstein

Open access · goldAbstract read
In one paragraph

Article in Frontiers in global women's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Microglia depletion facilitates the display of maternal behavior and alters activation of the maternal brain network in nulliparous female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Christina M RaganNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Eman I AhmedNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Erika M VitaleBehavioral Neuroscience Program, Department of Psychology, Michigan State University, East Lansing, MI, United States.
Katrina Linning-DuffyNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Stephanie M Miller-SmithBehavioral Neuroscience Program, Department of Psychology, Michigan State University, East Lansing, MI, United States.
Jamie MaguireDepartment of Neuroscience, Tufts University School of Medicine, Boston, MA, United States.
Joseph S LonsteinNeuroscience Program, Michigan State University, East Lansing, MI, United States.
Michigan State University · USTufts University · US

Funding

Neurobiological Control of Maternal AnxietyR01HD057962 · NICHD · MICHIGAN STATE UNIVERSITY · PI LONSTEIN, JOSEPH S · 2010 to 2014
$1.5M
NICHD NIH HHS R01 HD057962
6 · The paper itself

Abstract

Upregulation of the inhibitory neurotransmitter, GABA, is involved in many of the behavioral differences between postpartum and nulliparous female rodents. This is evidenced by studies showing that pharmacological blockade of GABAergic activity impairs maternal caregiving and postpartum affective behaviors. However, the influence of motherhood on the capacity for GABA synthesis or release in the medial prefrontal cortex (mPFC; brain region involved in many social and affective behaviors) is not well-understood. Western blotting was used to compare postpartum and nulliparous rats in protein levels of the 65-kD isoform of glutamic acid decarboxylase (GAD

Indexed as

anxietyGABAlactationmaternal behaviormedial prefrontal cortexreproductive state

Identifiers

PMID35211693
PMCPMC8861351
OpenAlexW4210847586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.