ArticleJTCVS open2021
Bioprosthetic aortic valve diameter and thickness are directly related to leaflet fluttering: Results from a combined experimental and computational modeling study.
Article in JTCVS open, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 48 citations in OpenAlex.
- A Whole-Heart Fluid-Structure Interaction Model for Transcatheter Mitral Valve Repair in Primary Mitral Regurgitation.Annals of biomedical engineering · 2026Article
- Patient-Specific Analysis of Ventricular Vortex Formation and Flow Energetics in Rheumatic and Calcific Mitral Stenosis.Annals of biomedical engineering · 2026Article
- Parameterized shape optimization of a bi-leaflet heart valved conduit for pediatric applications.Engineering with computers · 2026Article
- Modes of Leaflet Fluttering: Quantitative Characterization of a Bovine Bioprosthetic Heart Valve.Annals of biomedical engineering · 2026Article
- A numerical framework for preprocedural prosthetic valve positioning and hemodynamic evaluation.Biomechanics and modeling in mechanobiology · 2025Article
- A fluid-structure interaction model of the zebrafish aortic valve.Journal of biomechanics · 2025Article
- Computational construction and design optimization of a novel tri-tube heart valve.Biomechanics and modeling in mechanobiology · 2025Article
- The importance of tissue science and valve design in relation to durability and hemodynamics of the DurAVR aortic heart valve.Frontiers in cardiovascular medicine · 2025Review
- Analysis of Fluid-Structure Interaction Mechanisms for a Native Aortic Valve, Patient-Specific Ozaki Procedure, and a Bioprosthetic Valve.Annals of biomedical engineering · 2024Article
- Simulating cardiac fluid dynamics in the human heart.PNAS nexus · 2024Article
- An immersed peridynamics model of fluid-structure interaction accounting for material damage and failure.Journal of computational physics · 2023Article
- Comparison of Immersed Boundary Simulations of Heart Valve Hemodynamics Against In Vitro 4D Flow MRI Data.Annals of biomedical engineering · 2023Article
- In Vitro Proof of Concept of a First-Generation Growth-Accommodating Heart Valved Conduit for Pediatric Use.Macromolecular bioscience · 2023Article
- A parametric geometry model of the aortic valve for subject-specific blood flow simulations using a resistive approach.Biomechanics and modeling in mechanobiology · 2023Article
- A Doppler-exclusive non-invasive computational diagnostic framework for personalized transcatheter aortic valve replacement.Scientific reports · 2023Article
- A model of fluid-structure and biochemical interactions for applications to subclinical leaflet thrombosis.International journal for numerical methods in biomedical engineering · 2023Article
- A Nodal Immersed Finite Element-Finite Difference Method.Journal of computational physics · 2023Article
- Biomechanical Engineering Analysis of Pulmonary Valve Leaflet Hemodynamics and Kinematics in the Ross Procedure.Journal of biomechanical engineering · 2023Article
- Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models.IEEE transactions on bio-medical engineering · 2022Article
- Computational modeling of drug dissolution in the human stomach: Effects of posture and gastroparesis on drug bioavailability.Physics of fluids (Woodbury, N.Y. : 1994) · 2022Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
objectiveBioprosthetic heart valves (BHVs) are commonly used in surgical and percutaneous valve replacement. The durability of percutaneous valve replacement is unknown, but surgical valves have been shown to require reintervention after 10 to 15 years. Further, smaller-diameter surgical BHVs generally experience higher rates of prosthesis-patient mismatch, which leads to higher rates of failure. Bioprosthetic aortic valves can flutter in systole, and fluttering is associated with fatigue and failure in flexible structures. The determinants of flutter in BHVs have not been well characterized, despite their potential to influence durability.
methodsWe use an experimental pulse duplicator and a computational fluid-structure interaction model of this system to study the role of device geometry on BHV dynamics. The experimental system mimics physiological conditions, and the computational model enables precise control of leaflet biomechanics and flow conditions to isolate the effects of variations in BHV geometry on leaflet dynamics.
resultsBoth experimental and computational models demonstrate that smaller-diameter BHVs yield markedly higher leaflet fluttering frequencies across a range of conditions. The computational model also predicts that fluttering frequency is directly related to leaflet thickness. A scaling model is introduced that rationalizes these findings.
conclusionsWe systematically characterize the influence of BHV diameter and leaflet thickness on fluttering dynamics. Although this study does not determine how flutter influences device durability, increased flutter in smaller-diameter BHVs may explain how prosthesis-patient mismatch could induce BHV leaflet fatigue and failure. Ultimately, understanding the effects of device geometry on leaflet kinematics may lead to more durable valve replacements.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.