Evidence map›Paper›PMID 35211631›Full record

ArticleJournal of immunology research2022

Impact of Notch3 Activation on Aortic Aneurysm Development in Marfan Syndrome.

Kathryn Jespersen, Chenxin Li, Rishi Batra, Christopher A Stephenson, Paul Harding, Kylie Sestak, Ryan T Foley, Harrison Greene, Trevor Meisinger, Jason R Cook and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Kathryn JespersenDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Chenxin LiDepartment of Ophthalmology, Shanghai Jiao Tong University, Shanghai, China.
Rishi BatraDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Christopher A StephensonDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Paul HardingDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Kylie SestakDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Ryan T FoleyDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Harrison GreeneDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Trevor MeisingerDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Jason R CookDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
B Timothy BaxterDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.
Wanfen XiongDepartment of Surgery, University of Nebraska Medical Center, Omaha, NE 68198-7690, USA.ORCID https://orcid.org/0000-0002-8971-9710
University of Nebraska Medical Center · USShanghai Jiao Tong University · CN

Funding

MMP REGULATION BY DOXYCYCLINE IN AORTIC ANEURYSMR01HL062400 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BAXTER, BERNARD TIMOTHY · 2000 to 2015
$3.9M
Role of early SMC phenotypic switch in the aortic pathology of Marfan syndromeR01HL130623 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI XIONG, WANFEN · 2016 to 2019
$1.5M
NHLBI NIH HHS R01 HL062400NHLBI NIH HHS R01 HL130623
6 · The paper itself

Abstract

backgroundThe leading cause of mortality in patients with Marfan syndrome (MFS) is thoracic aortic aneurysm and dissection. Notch signaling is essential for vessel morphogenesis and function. However, the role of Notch signaling in aortic pathology and aortic smooth muscle cell (SMC) differentiation in Marfan syndrome (MFS) is not completely understood.

methodsRNA-sequencing on ascending aortic tissue from a mouse model of MFS,

resultsThe murine RNA-sequencing data were validated with mouse and human MFS aortic tissue, demonstrating elevated Notch3 activation in MFS. Data further revealed that upregulation and activation of Notch3 were concomitant with increased expression of SMC contractile markers. Inhibiting Notch3 activation with DAPT attenuated aortic enlargement and improved survival of

conclusionsOur data demonstrated that matrix abnormalities in the aorta of MFS are associated with increased Notch3 activation. Enhanced Notch3 activation in MFS contributed to aortic aneurysm formation in MFS. This might be mediated by inducing a contractile phenotypic change of SMC. Our results suggest that inhibiting Notch3 activation may provide a strategy to prevent and treat aortic aneurysms in MFS.

Indexed as

AdipokinesAnimalsAortaAortic AneurysmDiaminesDisease Models, AnimalElastinFibrillin-1HumansMarfan SyndromeMiceMice, Inbred C57BLMice, Mutant StrainsMolecular Targeted TherapyMyocytes, Smooth MuscleReceptor, Notch324-diamino-5-phenylthiazoleAdipokinesDiaminesElastinFbn1 protein, mouseFibrillin-1Notch3 protein, mouseReceptor, Notch3Thiazoles

Identifiers

PMID35211631
PMCPMC8863478
OpenAlexW4212998704

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.