SynthesisFrontiers in surgery2022
Efficacy and Safety of Sphincter-Preserving Surgery in the Treatment of Complex Anal Fistula: A Network Meta-Analysis.
Synthesis in Frontiers in surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Systematic review and network meta-analysis of cryptoglandular complex anal fistula treatment: evaluation of surgical strategies.Updates in surgery · 2025Pooled it
- Comparison of clinical outcomes of anal fistula plug and endoanal advancement flap repair treating the complex anal fistula: a systematic review and meta-analysis.Updates in surgery · 2023Pooled it
- Omission of core authorship and paradigm shifts like TROPIS in anal fistula bibliometric analysis.Updates in surgery · 2026Article
- Changes of Serum VEGF, VEGFR2 and Their Relationship with Pathogenic Bacterial Infection, and Wound Healing in Patients After Anal Fistula Surgery.Digestive diseases and sciences · 2026Article
- Research progress of stem cell transplantation in the treatment of anal fistula.Surgery today · 2026Review
- Clinical efficacy and failure-related factors of the loose-seton procedure combined with transanal opening of the intersphincteric space technique (LoSet-TROPlS) in the treatment of complex anal fistulas.Techniques in coloproctology · 2026Article
- Why it is not a good idea to perform a meta-analysis comprising only randomized controlled trials in complex anal fistula?Updates in surgery · 2026Article
- Letter to Editor: "Transanal opening of intersphincteric space (TROPIS) for high complex fistulas: update from the innovator after a decade's experience".International journal of surgery (London, England) · 2026Article
- Pathophysiological mechanisms and clinical management of type 2 diabetes mellitus complicated with anal fistula.Frontiers in surgery · 2026Review
- Why Transanal Opening of Intersphincteric Space (TROPIS) is effective in high complex anal fistula?Surgery open science · 2025Article
- Feasibility and safety of intersphincteric incision and fistula ligation for the treatment of transphincteric anal fistula.BMC surgery · 2025Article
- Transanal Opening of the Intersphincteric Space (TROPIS) Is Effective in Managing High Complex as It Is Based on Garg Cardinal Principles.Digestive diseases and sciences · 2025Article
- Evaluation of the RIFER procedure in treating high intersphincteric anal fistulas.Frontiers in medicine · 2025Article
- Exosomal miR-93-3p targets EIF4EBP1 to regulate macrophage polarization and accelerate wound healing post-anal fistula surgery.Frontiers in pharmacology · 2025Article
- Combined Parks Seton placement and transanal sphincterotomy improves outcome and reduces recurrence in high-position complex anal fistula.American journal of translational research · 2025Article
- A modified sphincter-preserved procedure for high complex anal fistulas: a preliminary study.Gastroenterology report · 2025Article
- Article
- Structured magnetic resonance imaging and endoanal ultrasound anal fistulas reporting template (SMART): An interdisciplinary Delphi consensus.World journal of gastrointestinal surgery · 2024Article
- Achieving a high cure rate in complex anal fistulas: understanding the conceptual role of the Garg cardinal principles.Annals of coloproctology · 2024Article
- The management of complex fistula in ano by transanal opening of the intersphincteric space (TROPIS): short-term results.Annals of coloproctology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere are many surgical methods of sphincter preservation in treating complex anal fistula, but the therapeutic effects of each operation are different. Therefore, this study aimed to compare the impact of other treatment methods through a network meta-analysis to evaluate the best sphincter preservation method for treating complex anal fistula.
methodsWe searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, VIP Journal Database, and the Wanfang Database to collate randomized controlled trials on sphincter-preserving surgery for complex anal fistula.
resultsA total of 29 articles were included in this meta-analysis. The cure rates showed no statistically significant differences between any two interventions (
conclusionAccording to the existing literature data, for patients with complex anal fistula, TROPIS may be the surgical method with the highest cure rate, SCT may be the treatment method with the lowest recurrence rate, and imLIFT may be the surgical method with the lowest incidence of postoperative complications. SYSTEMATIC REVIEW REGISTRATION: PROSPERO, identifier: CRD42020221907.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.