ArticleFrontiers in cell and developmental biology2021
Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging.
Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
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- Polystyrene nanoplastics disrupt epididymal initial segment by perturbing NK cell differentiation and epithelial homeostasis.Journal of nanobiotechnology · 2025Article
- Spatiotemporal mapping reveals Ccl8Clinical and translational medicine · 2025Article
- Age-related reproductive performance and transcriptome profiling of testis in male blue catfish, Ictalurus furcatus.BMC genomics · 2025Article
- SATINN v2: automated image analysis for mouse testis histology with multi-laboratory data integration†.Biology of reproduction · 2025Article
- Genomic Insights into Fertilization: Tracing PLCZ1 Orthologs Across Amphibian Lineages.Genome biology and evolution · 2025Article
- AlphaPPIweb: an integration platform for protein-protein interaction prediction and evaluation.American journal of cancer research · 2025Article
- Transcriptome-wide association identifiesiMeta · 2024Article
- IFIT3 mediates TBK1 phosphorylation to promote activation of pDCs and exacerbate systemic sclerosis in mice.Clinical and translational medicine · 2024Article
- Reproductive Ageing: Current insights and a potential role of NAD in the reproductive health of aging fathers and their children.Reproduction (Cambridge, England) · 2024Review
- Exposure to female olfactory cues hastens reproductive ageing and increases mortality when mating in male mice.Proceedings. Biological sciences · 2024Article
- Human Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Rescue Testicular Aging.Biomedicines · 2024Article
- Functional Insight into hTRIR.Current molecular medicine · 2024Article
- Hyperhomocysteinemia lowers serum testosterone concentration via impairing testosterone production in Leydig cells.Cell biology and toxicology · 2023Article
- Exploring biomarkers of premature ovarian insufficiency based on oxford nanopore transcriptional profile and machine learning.Scientific reports · 2023Article
- Single-cell RNA sequencing reveals the local cell landscape in mouse epididymal initial segment during aging.Immunity & ageing : I & A · 2023Article
- Article
- Transcriptome profiling of the initial segment and proximal caput of mouse epididymis.Frontiers in endocrinology · 2023Article
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elderly males undergo degenerative fertility and testicular endocrine function that jeopardize the reproductive health and well-being. However, the mechanisms underlying reproductive aging are unclear. Here, we tried to address this by investigating the phenotypes and transcriptomes of seven regions of the male mouse reproductive tract: the testis, efferent ductules, initial segment, caput, corpus and cauda epididymidis, and vas deferens, in adult (3 months) and aged (21 months) mice. Quantitative PCR, immunohistochemistry, immunofluorescent staining, and enzyme-linked immunosorbent assay were performed for the analysis of gene expression in mice, human tissues, and semen samples. Aged male mice showed both systematic and reproductive changes, and remarkable histological changes were detected in the testis and proximal epididymis. Transcriptomes of the male reproductive tract were mapped, and a series of region-specific genes were identified and validated in mouse and/or human tissues, including Protamine 1 (
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