Evidence map›Paper›PMID 35211420›Full record

ArticleFrontiers in cellular and infection microbiology2021

Gastrointestinal Autonomic Neuropathy Exacerbates Gut Microbiota Dysbiosis in Adult Patients With Type 2 Diabetes Mellitus.

Yuhui Du, Qiongli Neng, Yu Li, Yongbo Kang, Liqiong Guo, Xinwei Huang, Minghui Chen, Fan Yang, Jingan Hong, Shuai Zhou and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 38 citations in OpenAlex.

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  19. Reduced abundance ofFrontiers in pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Yuhui DuMedical Faculty, Kunming University of Science and Technology, Kunming, China.
Qiongli NengEndocrinology Branch, The First People's Hospital of Yunnan Province, Kunming, China.
Yu LiMedical Faculty, Kunming University of Science and Technology, Kunming, China.
Yongbo KangSchool of Basic Medical Sciences, Shanxi Medical University, Taiyuan, China.
Liqiong GuoMedical Faculty, Kunming University of Science and Technology, Kunming, China.
Xinwei HuangMedical Faculty, Kunming University of Science and Technology, Kunming, China.
Minghui ChenMedical Faculty, Kunming University of Science and Technology, Kunming, China.
Fan YangNutrition Department, The First People's Hospital of Yunnan Province, Kunming, China.
Jingan HongNutrition Department, The First People's Hospital of Yunnan Province, Kunming, China.
Shuai ZhouNeurosurgery Department, The First People's Hospital of Yunnan Province, Kunming, China.
Jianhua ZhaoNeurosurgery Department, The First People's Hospital of Yunnan Province, Kunming, China.
Fubing YuDigestive System Department, Affiliated Hospital of Yunnan University, Kunming, China.
Heng SuEndocrinology Branch, The First People's Hospital of Yunnan Province, Kunming, China.
Xiangyang KongMedical Faculty, Kunming University of Science and Technology, Kunming, China.
First People's Hospital of Yunnan Province · CNKunming University of Science and Technology · CNShanxi Medical University · CNSouthern University of Science and Technology · CNYunnan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe diabetic autonomic neuropathy is one of the most common complications in type 2 diabetes mellitus (T2DM), especially gastrointestinal autonomic neuropathy (GAN), which occurs in up to 75% of patients. The study aimed to investigate the gut microbiota composition, structure, and function in T2DM patients with GAN (T2DM_GAN) and set up a link between gut microbiota and clinical characteristics of patients.

methodsDNA was extracted from fecal samples of three groups using the kit method: healthy volunteers (n = 19), the patients with T2DM (n = 76), and T2DM_GAN (n = 27). Sequencing of 16S ribosomal DNA was performed using the MiSeq platform.

resultsAccording to the clinical data, higher age, lower triglyceride, and lower body mass index were the main features of patients with T2DM_GAN. The gut microbiota analysis showed that Bacteroidetes, Firmicutes, and Proteobacteria constituted the three dominant phyla in healthy individuals. In addition, the gut microbiota structure and function of T2DM_GAN patients were clearly different from that of T2DM patients. T2DM patients were characterized by Fusobacteria, Fusobacteriia, Fusobacteriales, Fusobacteriaceae,

conclusionsGAN exacerbated gut microbiota dysbiosis in adult patients with T2DM. The findings indicated that phyla Fusobacteria and class Gammaproteobacteria were closely related to the occurrence of T2DM. Especially the latter may promote T2DM_GAN.

Indexed as

Diabetes Mellitus, Type 2Gastrointestinal MicrobiomeAdultDysbiosisFecesGastrointestinal TractHumansRNA, Ribosomal, 16SRNA, Ribosomal, 16Sdiagnosisgastrointestinal autonomic neuropathygastrointestinal symptomsgut microbiotatype 2 diabetes mellitus

Identifiers

PMID35211420
PMCPMC8861497
OpenAlexW4210862595

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.